Evidence supporting the use of: Vitamin B9 (calcium methylfolate)
For the body system: Male Reproductive System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B9, particularly in the form of calcium methylfolate, is scientifically recognized for its role in supporting the male reproductive system, particularly in spermatogenesis and maintaining sperm quality. Folate is essential for DNA synthesis, repair, and methylation, which are crucial processes during the production and maturation of sperm. Several studies have indicated that folate deficiency in men is associated with lower sperm concentration, reduced motility, and increased sperm DNA damage. Randomized controlled trials have shown that supplementation with folate (often combined with other vitamins and minerals) can lead to modest improvements in sperm count and quality, although results are mixed and not universally conclusive.

Calcium methylfolate is a bioactive form of folate that is more readily absorbed and utilized by the body compared to synthetic folic acid. This is particularly relevant for individuals with MTHFR gene polymorphisms, who may have impaired folic acid metabolism. While folate is more famously known for its role in preventing neural tube defects in offspring, its importance in male fertility has become increasingly recognized in recent years. However, more large-scale, high-quality studies are needed to unequivocally establish the degree of benefit for male fertility outcomes, such as live birth rates. In summary, there is moderate scientific evidence supporting the use of Vitamin B9 in maintaining and supporting aspects of the male reproductive system.

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