Evidence supporting the use of: Vitamin E (alpha tocopherol)
For the body system: Male Reproductive System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E (alpha tocopherol) is an antioxidant that has been investigated for its role in supporting the male reproductive system, particularly in relation to fertility. Scientific studies, primarily in animal models, have shown that Vitamin E deficiency can lead to impaired spermatogenesis and testicular degeneration. Some human studies have suggested that Vitamin E supplementation may improve sperm motility and reduce oxidative stress in the semen of infertile men, which is an important factor in male infertility. For example, a few randomized controlled trials have reported modest improvements in semen quality or pregnancy rates when Vitamin E was given alone or in combination with other antioxidants. However, the results are inconsistent, and systematic reviews often conclude that the evidence is limited and of low to moderate quality.

Historically, Vitamin E was first discovered because of its essential role in preventing fetal resorption in rats, which led to its association with reproductive health. This has contributed to its traditional use for male fertility support. Nevertheless, while there is biological plausibility given its antioxidant properties and some positive findings, robust clinical evidence in humans is lacking. Major medical guidelines do not currently recommend routine Vitamin E supplementation for male infertility, except in cases of confirmed deficiency. In summary, there is some scientific evidence supporting its use, but it is not strong or conclusive.

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