Evidence supporting the use of: Vitamin E (alpha-tocopherol)
For the body system: Male Reproductive System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin E (alpha-tocopherol) has been investigated for its role in supporting the male reproductive system, particularly with respect to male fertility. The scientific justification for its use is primarily based on its function as a lipid-soluble antioxidant. Oxidative stress in the testes and seminal plasma can impair sperm motility, viability, and overall fertility. By neutralizing free radicals, Vitamin E helps protect sperm membrane integrity and function. Several animal studies have shown that Vitamin E supplementation can improve sperm count, motility, and fertilization rates. In humans, some clinical studies suggest that Vitamin E supplementation, alone or in combination with other antioxidants, may improve certain semen parameters and reduce DNA damage in sperm, particularly in men with infertility linked to oxidative stress. However, results are mixed, with some trials showing no significant benefit. The evidence is strongest for its antioxidant effect, but improvements in actual pregnancy rates are less well documented. The use of Vitamin E for this purpose is also supported by its established role in preventing testicular degeneration in animal models with Vitamin E deficiency. Overall, while Vitamin E is not a panacea for male infertility, there is moderate scientific evidence supporting its use as an adjunct in cases where oxidative stress is implicated.

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