Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin E, including beta-tocopherol, is supported by scientific research for its role in male reproductive health, primarily due to its antioxidant properties. Vitamin E is known to protect cell membranes from oxidative damage, which is particularly relevant to sperm cells that are rich in polyunsaturated fatty acids and especially susceptible to oxidative stress. Several animal studies have demonstrated that Vitamin E deficiency can lead to testicular degeneration, reduced sperm motility, and decreased fertility. In humans, some clinical trials have indicated that Vitamin E supplementation may improve sperm quality, motility, and overall fertility outcomes, especially in men experiencing infertility related to oxidative stress. However, the quality and consistency of evidence in humans are mixed, with some studies showing benefit and others showing minimal or no effect. The majority of benefits appear to be in populations with existing fertility challenges or low antioxidant status. The use of Vitamin E to support male reproductive health is thus grounded in both mechanistic understanding and some clinical evidence, but more high-quality, large-scale randomized controlled trials are needed to firmly establish its efficacy. As a result, the evidence supports a moderate rating.

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