Vitamin E, particularly in the form of mixed tocotrienols, has been investigated for its role in supporting the male reproductive system, primarily due to its antioxidant properties. Oxidative stress is known to impair sperm function and quality, and antioxidants like Vitamin E can help neutralize free radicals, potentially improving reproductive health. Several animal studies have demonstrated that Vitamin E supplementation can enhance sperm motility, count, and overall fertility parameters. In human studies, results are somewhat mixed. Some clinical trials suggest that Vitamin E, alone or in combination with other antioxidants, may improve semen parameters and increase pregnancy rates in men with infertility issues. For instance, a 2019 meta-analysis found that antioxidant supplementation, including Vitamin E, was associated with improved sperm motility and concentration in subfertile men, though the evidence quality was moderate and the effects modest.

Tocotrienols, a less common but biologically active form of Vitamin E, have shown superior antioxidant activity compared to tocopherols in some laboratory settings. However, direct evidence in humans specifically using mixed tocotrienols for male reproductive health is limited. Most human data focus on alpha-tocopherol. Nevertheless, the established role of oxidative stress in male infertility and the general antioxidant effects of Vitamin E provide a scientific basis for its use, albeit with a moderate level of supporting evidence, particularly for tocotrienols.