Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Lithium is one of the most well-established and scientifically validated treatments for mania, particularly in the context of bipolar disorder. Its use dates back to the mid-20th century, when Australian psychiatrist John Cade discovered its mood-stabilizing properties in 1949. Since then, lithium has become the gold standard for acute management of manic episodes and for long-term mood stabilization.

Numerous randomized controlled trials, meta-analyses, and clinical guidelines support lithium’s efficacy in reducing the severity of manic symptoms. It is thought to exert its effects through modulation of neurotransmitter systems (such as serotonin and dopamine), inhibition of inositol monophosphatase, and neuroprotective actions that may involve second messenger systems and gene expression. Lithium’s effectiveness is reflected in its inclusion as a first-line agent in international guidelines, including those from the American Psychiatric Association (APA) and the National Institute for Health and Care Excellence (NICE).

Additionally, long-term studies show that lithium reduces the risk of relapse in bipolar disorder and has unique anti-suicidal properties. Its side effect profile and need for monitoring are well-characterized, which further supports its clinical use. In summary, lithium’s role in the treatment of mania is strongly supported by decades of scientific research and clinical experience.

More about Lithium
More about Mania

Other ingredients used for this condition

None

Other health conditions supported by Lithium

Alzheimer's Disease
Bipolar Mood Disorder
Depression
Mania
Mood Swings

Products containing Lithium

We currently have no products on Vitabase that contain this ingredient.