Synopsis

Source of validity: Scientific
Rating (out of 5): 2

β-Nicotinamide mononucleotide (NMN) is a precursor to nicotinamide adenine dinucleotide (NAD+), a molecule critical for cellular energy metabolism and various biological processes, including those in the brain. Interest in NMN supplementation arises from evidence that NAD+ levels decline with age, a phenomenon linked to age-associated cognitive decline. Preclinical studies in animal models have shown that NMN supplementation can enhance NAD+ levels in the brain, improve mitochondrial function, and reduce neuroinflammation, all of which are associated with better cognitive performance and memory in aged mice. For example, some studies have shown improved learning and memory in NMN-treated mice, possibly due to enhanced neurovascular function and reduced oxidative stress.

However, human clinical evidence is currently limited. A few small-scale studies suggest that NMN is safe and can increase NAD+ levels in humans, but robust data demonstrating significant cognitive benefits in people are lacking. Most claims regarding NMN for memory and brain function stem from animal research or mechanistic rationale rather than direct clinical proof. Thus, while the scientific rationale and preclinical findings are promising, the overall evidence supporting NMN for memory and brain function in humans is preliminary and not yet conclusive. Large, well-designed human trials are needed to confirm these effects and determine optimal dosing and safety for cognitive outcomes.

More about β-nicotinamide mononucleotide (NMN)
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Other health conditions supported by β-nicotinamide mononucleotide (NMN)

Products containing β-nicotinamide mononucleotide (NMN)

Designs For Health Liposomal NMN Synergy 1.7 fl oz (50 ml) liquid. Nonreturnable item.