Evidence supporting the use of: Coenzyme Q10 (CoQ10)
For the health condition: Memory and Brain Function
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Coenzyme Q10 (CoQ10) is a fat-soluble antioxidant that plays a crucial role in mitochondrial energy production. There is growing scientific interest in CoQ10’s effects on memory and brain function, primarily due to its antioxidant properties and its role in cellular energy metabolism. Some preclinical studies suggest that CoQ10 may help protect neurons from oxidative stress and improve mitochondrial function, both of which are implicated in neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. Animal studies have shown that CoQ10 supplementation can reduce markers of oxidative damage and may improve cognitive performance in models of neurodegenerative conditions.
Human evidence, however, remains limited and mixed. A few small clinical trials have investigated CoQ10 in people with neurodegenerative diseases or mild cognitive impairment, but results have been inconclusive or only modestly positive. For example, some studies in patients with Parkinson’s disease suggested a potential slowing of functional decline, but larger follow-up trials have not confirmed significant cognitive benefits. Studies specifically targeting healthy adults or those with mild memory complaints are rare, and most have found little or no measurable improvement in cognitive outcomes.
In summary, while there is a plausible scientific rationale and some early-stage research suggesting a potential neuroprotective effect of CoQ10, the clinical evidence supporting its use for memory and brain function is weak. More robust and larger-scale human studies are needed before CoQ10 can be recommended for this purpose with confidence.
More about coenzyme Q10 (CoQ10)
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Other ingredients used for Memory and Brain Function
2'-FucosyllactoseAcai berry
Acetyl L-carnitine
algal oil
alpha-pinene
amino acids
anchovies
anthocyanins
ashwagandha
asparagus
astaxanthin
Waterhyssop
beet
berry flavor
beta caryophyllene
Bifidobacterium longum
bilberry
black currant
black garlic
sesame
black tea
blackberry
blueberry
Indian frankincense
broccoli
caprylic acid
catechins
caterpillar mushroom
chaga mushroom
Chinese salvia root
choline
cinnamon
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
cordyceps
creatine monohydrate
turmeric
curcumin
d-alpha tocopherol
DHA (docosahexaenoic acid)
diallyl disulfide (DADS)
DPA (docosapentaenoic acid)
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish protein
folate
fruit and vegetable blend (proprietary)
fruit blend (proprietary)
ginkgo biloba
glycerophosphocholine (GPC)
gooseberry
gotu kola
grape
green tea
guarana
guayusa
hesperetin
huperzine A
inositol
jujube
kale
krill oil
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
l-carnitine
L-carnosine
L-serine
L-taurine
L-theanine
l-tyrosine
Lactobacillus reuteri
lecithin
lion's mane
lutein
luteolin
maca
mackerel
Marine lipid
Matcha
medium chain triglycerides (MCT)
Moringa
Muira puama
Acetyl-L-Tyrosine
Naringin
Niacin (vitamin B3)
Niacinamide (vitamin B3)
nicotinamide riboside
oat
oleic acid
olive
omega-3 fatty acids
ophiopogon root
perilla
phosphatidylcholine
phosphatidylserine
phospholipids
phytocannabinoids
pine bark
pollen
polygala root
pomegranate
pregnenolone
prolyl endopeptidase (PEP)
pumpkin
pyrroloquinoline disodium salt
quail egg
quercetin
reishi mushroom
resveratrol
Rhodiola
rutin
saffron
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
sardines
selenium
black ginger
specialized pro-resolving mediators (SPMs)
spinach
spirulina
strawberry
sulforaphane glucosinolate
Threonic acid
tocotrienols
tomato
Trans-pterostilbene
Almond fruit
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
velvet bean
Vinpocetine
vitamin B12
vitamin B6
vitamin C
vitamin D
vitamin D3
vitamin E
seaweed
Mulberry
Zinc
β-nicotinamide mononucleotide (NMN)
suma
jiaogulan
Tinospora cordifolia
lingzhi
Morus
root tuber
ferulic acid
chrysanthemum
cistanche
lotus seed
royal jelly
terpene lactones
purslane
Yerba mate
biota seed
goji berry
Algae
cocoa
AMP-activated protein kinase (AMPK)
ashitaba
1,3,7-Trimethylpurine-2,6-dione
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
5-methyltetrahydrofolate glucosamine
7,8-Dihydroxyflavone
arachidonic acid
apigenin
Aronia melanocarpa
anserine
Alpha glyceryl
andrographolide
avocado
Agmatine
Acetylcholine
amentoflavone
Agarwood
Acacetin
alpha-lipoic acid
anthocyanidins
ampelopsin
Acer truncatum
aniracetam
anthocyanosides
black seed
bilobalide
butylphthalide
beta-hydroxybutyrate
breadnut
Blepharis
Beef liver
baccosides
Bacopin
baicalein
Basidiomycota
Boswellia
brahmi
Bacopa
Blue-Green Alage
Bifidobacteria
bacoside
baicalin
bird\'s nest
centrophenoxine
Camellia sinensis
Centella triterpenes
Chinese mountain ant
cyanobacteria
Carnosine
catalpol
chebulic acid
cod liver oil
Codonopsis
cyanidin
cruciferous
Centella asiatica
cinnamic acid
chocolate
Chinese Ligustrum berry
creatine
catuaba
Convolvulus prostratus
crocetin
Convolvulus pluricaulis
Celastrus
cytidine
cola nut
Canscora
currant
carnosic acid
docosahexaenoic Acid
danshen
Dendrobium
decursin
decursinol
dibenzo-alpha pyrones
date
epicatechin
egg
ergothioneine
elk antler
emblicanin
eicosapentaenoic acid
Eucommia ulmoides
enokitake
folic acid
fucosterol
fo-ti
fish
flavanones
flavoglycosides
flavans
frankincense
flavanols
Flammulina velutipes
flavones
gallic acid
Ginsenosides
garcinol
ginkgetin
galantamine
Gypenoside
glucose
Glutamate
ginkgolides
Glycosphingolipids
galangin
ginkgo flavone glycoside
Ginkgoside
Guaranine
Glycine
ginkgoheteroside
Glucoraphanin
gastrodin
Honokiol
Hericenones
hazelnut
hydroxytyrosol
hericium mushroom
Homotaurine
isoliquiritigenin
Idebenone
isovitexin
icariin
Jatamansi
Kaempferol
Lycium
lemon balm
longan
lysophosphatidylcholine
linalool
Methylcobalamin
mangiferin
Myricetin
Monounsaturated fat
Methylxanthine
Marine fat
Mate
Methoxylated flavones
magnolol
NADH
Naringenin
Nardostachys
Nobiletin
Nervonic acid
oolong tea
Osthole
Phosphocreatine
Puerain
pyrroloquinoline quinone
Piperine
Puerarin
paraxanthine
Plankton
polysaccharides
Polydatin
polyunsaturated fat
Pleurotus eryngii
Phthalides
Periwinkle
punicalagins
paeoniflorin
Pycnogenol
Polygonum
Polygala
rosmarinic acid
Rehmannia
Rubiaceae
robusta coffee
Schizochytrium Oil
Soy
Schizochytrium
Sulbutiamine
Shellfish
Salmon Oil
Salidroside
Sialic acid
Shankhpushpi
Salvianolic acid
Schisandrins
Schizandrol A
Shilajit
Safranal
Sarcosine
Stilbenoid
Sulforaphane
Terminalia
Tumerone
Trichilia catigua
Taxillus chinensis
Tanshinone
Trichopus zeylanicus
Taurine
Turmerones
Triacetyluridine
Tiger Nut
Tremella
Uncaria
Uridine
Vincamine
Vitexin
Withanolides
Wogonin
Walnut
Xanthine
Xanthohumol
Xanthophyll
Xylaria nigripes
Xanthone
Yuzu
Yumberry
Yohimbine
Other health conditions supported by coenzyme Q10 (CoQ10)
Aging (prevention)Alzheimer's Disease
Angina
Apathy
Arrhythmia
Arteriosclerosis
Athletic and Exercise Aids
Cancer Treatment (reducing side effects)
Cardiac Arrest
Cardiovascular Disease
Chemotherapy (reducing side effects)
Circulation (poor)
Congestive Heart Failure
Depression
Diabetes
Endurance (lack of)
Energy (lack of)
Exercise
Fatigue
Fibromyalgia Syndrome
Free Radical Damage
Heart (weakness)
Heart Fibrillation or Palpitations
Hypertension
Memory and Brain Function
Migraine
Multiple Sclerosis
Muscle Tone (lack of)
Muscular Dystrophy
Nerve Damage
Oral Surgery
Parkinson's Disease
Peripheral Neuropathy
Rheumatoid Arthritis
Tinnitus
Products containing coenzyme Q10 (CoQ10)
Pure Encapsulations
Athletic Nutrients
Douglas Laboratories
Citrus-Q10 ™
Douglas Laboratories
Co-Enzyme Q10 Softgel
Douglas Laboratories
Coenzyme Q-10 with Lipoic Acid
Douglas Laboratories
Coenzyme Q-10 with Lipoic Acid
Integrative Therapeutics
CoQ10
Integrative Therapeutics
COQ10 100 mg Tropical
Pure Encapsulations
CoQ10 120 mg
Pure Encapsulations
CoQ10 120 mg
Pure Encapsulations
CoQ10 120 mg
Integrative Therapeutics
COQ10 200 mg Chocolate 30 chew tabs
Pure Encapsulations
CoQ10 250 mg
Pure Encapsulations
CoQ10 30 mg
Pure Encapsulations
CoQ10 500 mg
Pure Encapsulations
CoQ10 60 mg
Pure Encapsulations
CoQ10 60 mg
Pure Encapsulations
CoQ10 60 mg
Pure Encapsulations
CoQ10 l-Carnitine Fumarate
Thorne
CoQ10 Q-Best 100
Metagenics
CoQ10 ST®-100 mg
Metagenics
CoQ10 ST-100 mg
Metagenics
CoQ10 ST-200 mg
Integrative Therapeutics
Detoxication Factors
Integrative Therapeutics
Detoxication Factors
Pure Encapsulations
Energize Plus™ Pure Pack
Pure Encapsulations
Hair/Skin/Nails Ultra
Thorne
Heart Health Complex Q-10 Plus
Integrative Therapeutics
K-PAX MitoNutrients
Vitabase
Life's Essentials Plus
Designs For Health
Mito-NR™
Pure Encapsulations
Mitochondria-ATP
Designs For Health
Mitochondrial NRG™
Pure Encapsulations
NeuroMood Pure Pack
Metagenics
NutraGems® CoQ10 300
Pure Encapsulations
O.N.E.™ Multivitamin
Pure Encapsulations
O.N.E.™ Multivitamin
Pure Encapsulations
O.N.E.™ Multivitamin
Thorne
Omega-3 w/ CoQ10
Thorne
Ovarian Care
Integrative Therapeutics
ProThrivers Wellness Flav Complex
Pure Encapsulations
PureGenomics® UltraMultivitamin
Designs For Health
Q-Evail® 100
Designs For Health
Q-Evail® 200
Pure Encapsulations
Q-Gel® (Hydrosoluble™ CoQ10) 100 mg
Thorne
Red Yeast Rice + CoQ10 Choleast
Pure Encapsulations
Renual
Pure Encapsulations
RevitalAge™ Nerve
Pure Encapsulations
RevitalAge™ Ultra
Designs For Health
RYR Synergy™
Pure Encapsulations
SR-CoQ10 with PQQ
Vitabase
Super Fat Burner
Pure Encapsulations
Ubiquinol-QH 100 mg
Pure Encapsulations
Ubiquinol-QH 200 mg
Pure Encapsulations
Ubiquinol VESIsorb®
Integrative Therapeutics
UBQH 100 mg
Douglas Laboratories
Ultra Preventive 50+ -EZ Swallow
Douglas Laboratories
Ultra Preventive One Daily
Pure Encapsulations
Ultra Pure Pack
Pure Encapsulations
UltraDetox 10-Day Pure Pack
Pure Encapsulations
UltraNutrient®
Pure Encapsulations
UltraNutrient®
Pure Encapsulations
UltraNutrient®
Metagenics
Wellness Essentials Brain Health Daily Packs