Evidence supporting the use of: Nerve growth factor
For the health condition: Memory and Brain Function

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Nerve Growth Factor (NGF) is a neurotrophin critical for the growth, maintenance, and survival of neurons. Scientific interest in NGF as a potential therapeutic agent for memory and brain function arises from its demonstrated roles in neuroprotection, synaptic plasticity, and neuronal repair mechanisms. Preclinical studies in animal models have shown that NGF administration can improve cognitive performance and reduce neurodegeneration, particularly in models of Alzheimer’s disease (AD). For example, direct delivery of NGF to the brain in rodent models has been shown to rescue cholinergic neurons and enhance learning and memory tasks.

In humans, the evidence is more limited but promising. Early-stage clinical trials, including intracerebral NGF gene therapy in AD patients, have reported some neuroprotective effects and hints of cognitive stabilization, but these studies often involve small sample sizes and are accompanied by delivery challenges and side effects. There is not yet robust, large-scale clinical trial data to confirm efficacy for memory improvement or widespread brain function enhancement in humans. Thus, while there is a scientific basis for NGF's potential in supporting memory and brain function, the current evidence is moderate and largely preclinical or early-phase clinical, warranting a cautious and investigational approach.

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Products containing Nerve growth factor

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