Evidence supporting the use of: Trans-pterostilbene
For the health condition: Memory and Brain Function

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Trans-pterostilbene is a naturally occurring stilbene compound, structurally similar to resveratrol, found in blueberries and Pterocarpus marsupium. Its use for supporting memory and brain function is based primarily on preclinical scientific evidence, with limited human data available. Animal studies have demonstrated that pterostilbene can cross the blood-brain barrier and may exert neuroprotective effects through antioxidant, anti-inflammatory, and anti-apoptotic pathways. In rodent models, pterostilbene administration has been associated with improved cognitive performance, such as enhanced memory and learning in maze tests. Mechanistic studies suggest that pterostilbene’s neuroprotective effects may involve upregulation of brain-derived neurotrophic factor (BDNF), reduction of oxidative stress markers, and modulation of signaling pathways related to neuroinflammation.

However, high-quality clinical trials in humans are lacking. The available human studies have focused largely on its safety, pharmacokinetics, and benefits for cardiometabolic health, with cognitive endpoints rarely assessed. Because of its higher bioavailability compared to resveratrol, pterostilbene is considered a promising candidate for future cognitive research. Until more robust human data are available, the evidence supporting its use for memory and brain function should be considered preliminary. In summary, while preclinical research supports a potential role for pterostilbene in cognitive health, further clinical trials are needed to confirm efficacy and optimal dosing in humans.

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Other ingredients used for Memory and Brain Function

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acai berry
acetyl l-carnitine
algal oil
alpha-pinene
amino acids
anchovies
anthocyanins
ashwagandha
asparagus
astaxanthin
waterhyssop
beet
berry flavor
beta caryophyllene
bifidobacterium longum
bilberry
black currant
black garlic
sesame
black tea
blackberry
blueberry
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broccoli
caprylic acid
catechins
caterpillar mushroom
chaga mushroom
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choline
cinnamon
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
cordyceps
creatine monohydrate
turmeric
curcumin
d-alpha tocopherol
DHA (docosahexaeonic acid)
diallyl disulfide (DADS)
DPA (docosapentaenoic acid)
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish protein
folate
fruit and vegetable blend (proprietary)
fruit blend (proprietary)
ginkgo biloba
glycerophosphocholine (GPC)
gooseberry
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grape
green tea
guarana
guayusa
hesperetin
huperzine A
inositol
jujube
kale
krill oil
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
l-carnitine
l-carnosine
l-serine
l-taurine
l-theanine
l-tyrosine
lactobacillus reuteri
lecithin
lion's mane
lutein
luteolin
maca
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marine lipid
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muira puama
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naringin
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
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oleic acid
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phosphatidylcholine
phosphatidylserine
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