Synopsis

Source of validity: Traditional
Rating (out of 5): 2

27-deoxyactein is a triterpene glycoside found in the root of Actaea racemosa (black cohosh), an herb traditionally used by Native American peoples and later adopted in Europe and North America for managing menopausal symptoms such as hot flashes, night sweats, and mood disturbances. The use of black cohosh (and by extension, its constituent 27-deoxyactein) for menopause is thus primarily rooted in traditional and historical herbal medicine practices.

Scientific studies have examined black cohosh extracts (often standardized to contain triterpene glycosides, including 27-deoxyactein), but the evidence for efficacy remains mixed. While some clinical trials and systematic reviews suggest a modest benefit in reducing vasomotor symptoms, others indicate no significant difference from placebo. Most studies do not isolate 27-deoxyactein as the sole active constituent; rather, whole-root or standardized extracts are tested. The mechanism of action is not fully understood, but black cohosh does not appear to exert estrogenic effects, and 27-deoxyactein's specific role is unclear.

Due to the preponderance of traditional use and limited, inconsistent scientific validation, the evidence supporting 27-deoxyactein (as part of black cohosh) for menopause is rated as 2/5. The ingredient is widely used in traditional herbal formulas, but robust, high-quality clinical data specifically supporting 27-deoxyactein is lacking.

More about 27-deoxyactein
More about Menopause

Other ingredients used for Menopause

27-deoxyactein
7-hydroxymatairesinol (HMR)
8-Prenylnaringenin
Achyranthes
Agnuside
Agrimonia pilosa
Akebia
Alchemilla
Alfalfa
Aloe vera
amaranth
Anemarrhena
anemarrhena asphodeloides
antler
Ashoka
ashwagandha
asparagus
astragalus
atractylodes
atractylone
banyan
barrenwort
bee pollen
bioflavonoids
black cohosh
black currant
black root
black seed
bupleurum falcatum
burdock
calcium
chaste tree
Chinese silkvine
Clary sage
Cnidium
cohosh
cordyceps
Crinum latifolium
Cynomorium
daidzein
damiana
danshen
DHEA
DHEA (dehydroepiandrosterone)
DIM (diindolylmethane)
dioscorea
dog rose
dong quai
dong quai root
durian
eleuthero
elk antler
equol (proprietary)
estrogen
Euryale seed
evening primrose oil
evening primrose oil
fenugreek
Ficus religiosa
fish oil
flaxseed
fo-ti
genistein
genistin
Glycetein
goji berry
hibiscus
HMR lignan
hops
horny goat weed
Hypericum
Indian frankincense
isoflavones
jujube
knotweed
kudzu
Labisia pumila
Lady's Mantle
lemon balm
licorice root
lignans
linden
lingzhi
Loranthus
lotus
Lycium
maca
macaenes
macamides
Marine lipid
Meadow sage
Melatonin
Miroestrol
Montanoa tomentosa
Moringa
Motherwort
Nettle
okra
omega-3 fatty acids
Ophiopogon
ophiopogon root
Phytoestrogens
pollen
Polygonum
pomegranate
Prickly Pear Cactus
Puerain
Pulsatilla
red clover
Rehmannia
rehmannia glutinosa
reishi mushroom
rhubarb
rockweed
Rooibos
root tuber
Rosa laevigata
rose
rose oil
royal jelly
Rubia cordifolia
Rubus
rue
saffron
sage
seaweed
smilax
Soy
soy isoflavones
Soy Protein
soybean
Stone Root
Valerian root
Vervain
Viburnum
vitamin B6
vitamin D
vitamin D3
vitamin E
Vitex Agnus-Castus
Wild yam
Withanolides
Yellow-Fruit Nightshade

Other health conditions supported by 27-deoxyactein

Hot Flashes
Menopause
PMS (general)
PMS Type P

Products containing 27-deoxyactein

We currently have no products on Vitabase that contain this ingredient.