Angelica gigas Nakai, commonly referred to as Korean Angelica, has a history of use in traditional East Asian medicine for women's health, particularly in gynecological conditions. In recent decades, scientific research has begun to explore its potential for alleviating menopausal symptoms. The root contains active compounds such as decursin and decursinol angelate, which have been studied for their estrogenic and neuroprotective effects.

Several preclinical studies suggest that extracts of Angelica gigas may exert estrogen-like effects by binding to estrogen receptors, potentially alleviating symptoms such as hot flashes and mood disturbances associated with menopause. For example, animal studies have reported improvements in menopause-related behaviors and reductions in bone loss. However, clinical evidence in humans remains limited. A small number of pilot human studies and randomized controlled trials have examined the effects of Angelica gigas (often in combination with other herbs) on menopausal symptoms, with mixed results and generally modest benefits.

Overall, while there is a traditional basis for its use and some emerging scientific evidence, the quality and quantity of clinical studies are insufficient for strong recommendations. Thus, the support for Angelica gigas Nakai in menopause management is based on early-stage scientific findings, warranting further research.