Evidence supporting the use of: Atractylone
For the health condition: Menopause

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Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Atractylone is a major sesquiterpenoid component found in Atractylodes species, especially Atractylodes macrocephala and Atractylodes lancea, both of which are widely used in Traditional Chinese Medicine (TCM). In TCM, the dried rhizome of Atractylodes (commonly known as "Bai Zhu") is traditionally prescribed for a range of conditions, including digestive issues, fatigue, and to "strengthen the spleen." Some TCM formulations containing Atractylodes are used for gynecological health, including symptoms that may overlap with menopause, such as fatigue and sweating. However, the direct use of atractylone itself, or Atractylodes, specifically for menopause is rooted primarily in tradition rather than modern clinical evidence. Scientific studies on atractylone have mostly focused on its anti-inflammatory, antioxidant, and gastrointestinal effects, with little to no direct research on menopause symptom relief. Therefore, its use for menopause is based on traditional herbal formulations rather than robust scientific validation. The evidence supporting its use for menopause is weak (rated 1), reflecting the lack of focused research and clinical trials addressing this specific indication.

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