Cistanche, a genus of desert plants used in traditional Chinese medicine (TCM), has a long-standing reputation for supporting vitality, kidney function, and sexual health. In the context of menopause, it is primarily included in herbal formulas to address symptoms such as fatigue, reduced libido, and mood changes—issues TCM attributes to "kidney deficiency," a common diagnosis in menopausal women according to TCM theory. Historical texts and modern TCM practitioners often recommend Cistanche as a tonic for women experiencing menopausal symptoms. However, there is minimal direct scientific evidence from clinical trials specifically evaluating Cistanche for the treatment or support of menopause in humans. Most available research focuses on its general adaptogenic effects, anti-fatigue properties, and potential neuroprotective activity. Some animal studies suggest anti-aging and cognitive benefits, but these are not directly connected to menopausal symptom relief. Therefore, while its use for menopause is supported by tradition and centuries of empirical use within TCM, robust scientific validation for this particular indication is lacking.