Evidence supporting the use of: Daidzein
For the health condition: Menopause
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Daidzein is an isoflavone, a type of phytoestrogen found primarily in soybeans and other legumes. Its use to support or treat menopause is grounded in scientific research, though the evidence is moderate rather than conclusive. Phytoestrogens like daidzein structurally resemble endogenous estrogens and can bind to estrogen receptors, exerting weak estrogenic or anti-estrogenic effects depending on the hormonal milieu. This has led to the hypothesis that daidzein may help alleviate menopausal symptoms such as hot flashes, night sweats, and mood disturbances, which are partly due to declining estrogen levels. Multiple randomized controlled trials (RCTs) and meta-analyses have investigated the effects of soy isoflavones, including daidzein, on menopausal symptoms. Some studies report a modest reduction in the frequency and severity of vasomotor symptoms, particularly hot flashes, compared to placebo. However, results are variable, and some trials find little or no benefit. The variability may be due to differences in study populations, isoflavone doses, duration, and individual differences in gut microbiota (which can affect daidzein metabolism to the more active compound equol). Systematic reviews generally conclude that soy isoflavones, including daidzein, are safe and may provide mild to moderate relief of menopausal symptoms, but are less effective than conventional hormone therapy. Overall, there is scientific rationale and some clinical evidence for their use, but effects are modest and not universal.
Other ingredients used for Menopause
7-hydroxymatairesinol (HMR)Alfalfa
Aloe vera
ashwagandha
asparagus
astragalus
black cohosh
black currant
Indian frankincense
bupleurum falcatum
burdock
calcium
chaste tree
cordyceps
damiana
DHEA (dehydroepiandrosterone)
DIM (diindolylmethane)
dog rose
dong quai root
eleuthero
evening primrose oil
fenugreek
fish oil
flaxseed
genistein
genistin
hibiscus
HMR lignan
hops
knotweed
jujube
kudzu
licorice root
lignans
maca
marine lipid
melatonin
moringa
motherwort
nettle
okra
omega-3 fatty acids
ophiopogon root
pollen
pomegranate
rehmannia glutinosa
reishi mushroom
rose oil
saffron
sage
soybean
valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
seaweed
wild yam
red clover
atractylodes
smilax
rubia cordifolia
bee pollen
lingzhi
root tuber
dioscorea
royal jelly
Equol (proprietary)
anemarrhena asphodeloides
barrenwort
goji berry
amaranth
soy isoflavones
27-deoxyactein
8-Prenylnaringenin
Akebia
Antler
Achyranthes
Alchemilla
Agrimonia pilosa
Agnuside
Ashoka
Anemarrhena
Atractylone
Black Seed
Banyan
Bioflavonoids
Black root
Chinese Silkvine
Cohosh
Clary sage
Cnidium
Cynomorium
Crinum latifolium
DHEA
Danshen
Daidzein
Durian
Dong Quai
Euryale seed
Elk antler
Evening Primrose Oil
Estrogen
Fo-Ti
Ficus religiosa
Glycetein
Horny Goat Weed
Hypericum
Isoflavones
Lycium
lemon balm
Lady's Mantle
Linden
Lotus
Loranthus
Labisia pumila
Macamides
Montanoa tomentosa
Meadow sage
Miroestrol
Macaenes
Ophiopogon
Puerain
Pulsatilla
Prickly Pear Cactus
Phytoestrogens
Polygonum
Rue
Rubus
Rockweed
Rehmannia
Rose
Rooibos
Rosa laevigata
Rhubarb
Soy
Soy Protein
Stone Root
Vervain
Viburnum
Vitex Agnus-Castus
Withanolides
Yellow-Fruit Nightshade
Other health conditions supported by Daidzein
Cancer (natural therapy for)Cancer (prevention)
Cancer Treatment (reducing side effects)
Cholesterol (high)
Diabetes
Hypertension
Menopause
Osteoporosis
Triglycerides (high)