Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol, which is found in cruciferous vegetables like broccoli and Brussels sprouts. Its use in menopause support is primarily based on its effects on estrogen metabolism. Specifically, DIM has been shown in laboratory and some small clinical studies to promote the formation of "good" estrogen metabolites (such as 2-hydroxyestrone) over "bad" ones (such as 16α-hydroxyestrone), which may be beneficial for hormonal balance during menopause.

However, the scientific evidence directly supporting DIM for the relief of menopausal symptoms (such as hot flashes, night sweats, or mood changes) is limited. Most of the research to date involves animal studies, test-tube experiments, or focuses on estrogen metabolism rather than clinical outcomes in menopausal women. A few small human trials suggest DIM can influence estrogen metabolite ratios, but robust, well-controlled trials examining symptom relief are lacking.

In summary, while there is a plausible biological mechanism and early data suggesting DIM may help modulate estrogen in a way that could support menopausal health, the overall evidence is weak and insufficient for strong clinical recommendations. More high-quality human studies are needed to establish its efficacy and safety for menopause symptom management.