Evidence supporting the use of: Ester derivatives (unspecified)
For the health condition: Menopause
Synopsis
Source of validity: Scientific
Rating (out of 5): 5
Ester derivatives, specifically esterified forms of estrogens (such as estradiol valerate, estradiol cypionate, and conjugated estrogens), are widely used in hormone replacement therapy (HRT) to treat symptoms of menopause. The scientific rationale is well-established: menopause leads to decreased endogenous estrogen production, which is associated with symptoms like hot flashes, night sweats, vaginal dryness, and increased risk of osteoporosis. Ester derivatives of estrogens are formulated to improve pharmacokinetics—providing more stable or prolonged hormone levels compared to unmodified hormones. Numerous randomized controlled trials and meta-analyses have shown that estrogen therapy (including esterified forms) reduces vasomotor symptoms, helps maintain bone density, and can improve quality of life in menopausal women. The use of these compounds is endorsed by clinical guidelines, such as those from the North American Menopause Society (NAMS) and the Endocrine Society, for women with significant menopausal symptoms. However, HRT is not without risks; studies such as the Women's Health Initiative (WHI) have detailed potential adverse events, including increased risks of thromboembolism and certain cancers, so individualized risk assessment is essential. In summary, the use of ester derivatives of estrogens for menopause is strongly supported by high-quality scientific evidence and decades of clinical experience.
More about Ester derivatives (unspecified)
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ashwagandha
asparagus
astragalus
black cohosh
black currant
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bupleurum falcatum
burdock
calcium
chaste tree
cordyceps
damiana
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DIM (diindolylmethane)
dog rose
dong quai root
eleuthero
evening primrose oil
fenugreek
fish oil
flaxseed
genistein
genistin
hibiscus
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knotweed
jujube
kudzu
licorice root
lignans
maca
marine lipid
melatonin
moringa
motherwort
nettle
okra
omega-3 fatty acids
ophiopogon root
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pomegranate
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rose oil
saffron
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soybean
valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
seaweed
wild yam
red clover
atractylodes
smilax
rubia cordifolia
bee pollen
lingzhi
root tuber
dioscorea
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Dong Quai
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