Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Genistin is a phytoestrogen, specifically an isoflavone glycoside found mainly in soybeans and other legumes. It is metabolized in the body to genistein, a compound that has been studied for its estrogen-like effects. The rationale for using genistin (and its aglycone genistein) in menopause is based on its structural similarity to estrogen, allowing it to bind to estrogen receptors and potentially alleviate menopausal symptoms such as hot flashes, night sweats, and bone loss. Clinical evidence supporting the use of genistin/genistein for menopausal symptoms is mixed. Some randomized controlled trials have shown modest improvements in vasomotor symptoms (e.g., hot flashes) among postmenopausal women consuming soy isoflavones, which include genistin. However, meta-analyses and reviews generally conclude that the effect size is small and that not all studies demonstrate significant benefits. The North American Menopause Society acknowledges that isoflavones may offer some relief for mild symptoms but are not as effective as hormone replacement therapy. There is scientific validation for the use of genistin (as part of soy isoflavones), but the quality and consistency of the evidence is moderate to low, which is reflected in the evidence rating. There is no major historical or traditional use of isolated genistin for menopause; rather, the scientific rationale comes from observational studies noting that populations with high dietary soy intake report fewer menopausal symptoms.

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