Evidence supporting the use of: Glycyrrhizic acid
For the health condition: Menopause

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Glycyrrhizic acid, the primary active compound in licorice root (Glycyrrhiza glabra), has a history of traditional use in various systems of medicine, including Traditional Chinese Medicine (TCM) and Ayurveda. In these contexts, licorice root is sometimes included in herbal formulas aimed at addressing menopausal symptoms such as hot flashes, irritability, or hormonal imbalance. The rationale for its use often hinges on its reputed estrogen-like activity, anti-inflammatory properties, and ability to harmonize other herbs in a formula.

From a scientific perspective, there is limited clinical evidence specifically evaluating glycyrrhizic acid or licorice root for menopause. Some in vitro and animal studies suggest that phytoestrogens in licorice may exert weak estrogenic effects, potentially influencing symptoms related to estrogen deficiency. However, well-controlled human trials are scarce, and most evidence is anecdotal or derived from traditional usage rather than rigorous scientific investigation. Furthermore, licorice root can have significant side effects, such as hypertension and hypokalemia, especially with long-term or high-dose use, raising safety concerns.

In summary, while glycyrrhizic acid’s use for menopause is primarily rooted in traditional practice, there is insufficient high-quality scientific data to strongly support its efficacy for menopausal symptoms. Its use should be approached cautiously, considering potential risks and the lack of robust clinical validation.

More about glycyrrhizic acid
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Other ingredients used for Menopause

7-hydroxymatairesinol (HMR)
Alfalfa
Aloe vera
ashwagandha
asparagus
astragalus
black cohosh
black currant
Indian frankincense
bupleurum falcatum
burdock
calcium
chaste tree
cordyceps
damiana
DHEA (dehydroepiandrosterone)
DIM (diindolylmethane)
dog rose
dong quai root
eleuthero
evening primrose oil
fenugreek
fish oil
flaxseed
genistein
genistin
hibiscus
HMR lignan
hops
knotweed
jujube
kudzu
licorice root
lignans
maca
marine lipid
melatonin
moringa
motherwort
nettle
okra
omega-3 fatty acids
ophiopogon root
pollen
pomegranate
rehmannia glutinosa
reishi mushroom
rose oil
saffron
sage
soybean
valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
seaweed
wild yam
red clover
atractylodes
smilax
rubia cordifolia
bee pollen
lingzhi
root tuber
dioscorea
royal jelly
Equol (proprietary)
anemarrhena asphodeloides
barrenwort
goji berry
amaranth
soy isoflavones
27-deoxyactein
8-Prenylnaringenin
Akebia
Antler
Achyranthes
Alchemilla
Agrimonia pilosa
Agnuside
Ashoka
Anemarrhena
Atractylone
Black Seed
Banyan
Bioflavonoids
Black root
Chinese Silkvine
Cohosh
Clary sage
Cnidium
Cynomorium
Crinum latifolium
DHEA
Danshen
Daidzein
Durian
Dong Quai
Euryale seed
Elk antler
Evening Primrose Oil
Estrogen
Fo-Ti
Ficus religiosa
Glycetein
Horny Goat Weed
Hypericum
Isoflavones
Lycium
lemon balm
Lady's Mantle
Linden
Lotus
Loranthus
Labisia pumila
Macamides
Montanoa tomentosa
Meadow sage
Miroestrol
Macaenes
Ophiopogon
Puerain
Pulsatilla
Prickly Pear Cactus
Phytoestrogens
Polygonum
Rue
Rubus
Rockweed
Rehmannia
Rose
Rooibos
Rosa laevigata
Rhubarb
Soy
Soy Protein
Stone Root
Vervain
Viburnum
Vitex Agnus-Castus
Withanolides
Yellow-Fruit Nightshade

Products containing glycyrrhizic acid

We currently have no products on Vitabase that contain this ingredient.