Evidence supporting the use of: Glycyrrhizic acid
For the health condition: Menopause

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Glycyrrhizic acid, the primary active compound in licorice root (Glycyrrhiza glabra), has a history of traditional use in various systems of medicine, including Traditional Chinese Medicine (TCM) and Ayurveda. In these contexts, licorice root is sometimes included in herbal formulas aimed at addressing menopausal symptoms such as hot flashes, irritability, or hormonal imbalance. The rationale for its use often hinges on its reputed estrogen-like activity, anti-inflammatory properties, and ability to harmonize other herbs in a formula.

From a scientific perspective, there is limited clinical evidence specifically evaluating glycyrrhizic acid or licorice root for menopause. Some in vitro and animal studies suggest that phytoestrogens in licorice may exert weak estrogenic effects, potentially influencing symptoms related to estrogen deficiency. However, well-controlled human trials are scarce, and most evidence is anecdotal or derived from traditional usage rather than rigorous scientific investigation. Furthermore, licorice root can have significant side effects, such as hypertension and hypokalemia, especially with long-term or high-dose use, raising safety concerns.

In summary, while glycyrrhizic acid’s use for menopause is primarily rooted in traditional practice, there is insufficient high-quality scientific data to strongly support its efficacy for menopausal symptoms. Its use should be approached cautiously, considering potential risks and the lack of robust clinical validation.

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Products containing glycyrrhizic acid

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