Evidence supporting the use of: Isoflavones (unspecified)
For the health condition: Menopause

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Isoflavones, particularly those derived from soy, are commonly used to support or treat menopausal symptoms, most notably hot flashes. Isoflavones are a class of phytoestrogens—plant-derived compounds that can weakly bind to estrogen receptors in the body. The rationale for their use is based on epidemiological observations that populations with high dietary intake of soy (such as in some Asian countries) report fewer menopausal symptoms compared to Western populations.

Scientific studies, including randomized controlled trials and meta-analyses, have shown mixed results. Some studies report modest reductions in the frequency and severity of hot flashes with isoflavone supplementation, while others show little to no effect when compared to placebo. A 2015 Cochrane review concluded that there is some evidence for a slight reduction in hot flushes and night sweats, but the effect is generally small and may not be clinically significant for all women. Additionally, the response to isoflavones can vary depending on individual factors such as gut microbiome composition, which affects isoflavone metabolism.

Overall, while there is scientific interest and some supportive evidence for the use of isoflavones in menopausal symptom management, the consensus is that effects are modest and not universally experienced. Further research is needed to better understand the populations that may benefit most. Isoflavones are generally considered safe for short-term use in this context.

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Products containing Isoflavones (unspecified)

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