The use of Polygonum species (such as Polygonum cuspidatum, also known as Japanese knotweed) for menopause support is primarily rooted in traditional medicine rather than robust scientific validation. In traditional Chinese medicine (TCM), certain Polygonum species have been used for various health concerns, including symptoms that may overlap with menopause, such as hot flashes, night sweats, and fatigue. These uses are often based on the herb’s purported ability to "nourish yin" or promote general vitality, rather than direct evidence related to menopausal physiology.

Scientifically, there is limited research specifically exploring Polygonum extracts for menopausal symptoms. While some compounds found in Polygonum, such as resveratrol, have been investigated for their potential estrogenic or antioxidant effects, clinical studies directly linking Polygonum or its extracts to menopausal symptom relief are lacking. Most available data are preclinical or animal studies, and the effects observed cannot be directly extrapolated to humans or to menopause management.

In summary, the use of Polygonum for menopause is supported mainly by historical and traditional practices, with minimal scientific evidence. Until more rigorous clinical trials are conducted, its use should be considered traditional rather than evidence-based.