Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Saffron (Crocus sativus) has increasingly been investigated for its potential to support menopause-related symptoms, especially mood disturbances such as depression and anxiety. Recent clinical studies provide preliminary scientific validation for its use. A key double-blind, randomized controlled trial published in 2018 in the journal Menopause found that saffron supplementation (28 mg/day for 12 weeks) significantly reduced depression and anxiety scores in perimenopausal women compared with placebo. The hypothesized mechanism involves saffron’s active constituents, including crocin and safranal, which may modulate neurotransmitter activity (notably serotonin) and possess antioxidant properties, both relevant to mood regulation. While saffron’s use for menopause is not as deeply rooted in traditional medicine as some other herbs, it has a longstanding history in Persian and traditional Asian medicine for mood, PMS, and women’s health. However, its application specifically for menopause is largely a modern, scientifically investigated development rather than a traditional one. Currently, evidence is promising but limited—most studies are small and focus primarily on mood symptoms rather than the broader spectrum of menopausal complaints (such as hot flashes or bone health). No major safety concerns have been identified at typical supplemental doses, but larger, more comprehensive trials are needed. In summary, saffron shows scientifically credible, moderate evidence for supporting mood-related symptoms in menopause, earning a rating of 3 out of 5.

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Pure Encapsulations Daily Calm
Designs For Health Mood-Stasis™