Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Soy isoflavones are plant-derived compounds classified as phytoestrogens due to their structural similarity to human estrogen. They have been extensively studied for their potential to alleviate menopausal symptoms, particularly hot flashes and night sweats. The scientific rationale for their use is based on their ability to bind to estrogen receptors and exert weak estrogenic or anti-estrogenic effects, which may help compensate for the declining estrogen levels experienced during menopause. Several randomized controlled trials and meta-analyses have investigated the efficacy of soy isoflavones for menopausal symptom relief. A 2021 meta-analysis published in JAMA Network Open found that soy isoflavone supplementation modestly reduced the frequency and severity of vasomotor symptoms, such as hot flashes, compared to placebo. However, the magnitude of the effect is generally small and results across studies are mixed, with some trials showing significant benefits and others showing minimal or no effect. Safety profiles for soy isoflavones are generally favorable, and they are often considered an alternative for women who cannot or do not wish to use hormone replacement therapy. In summary, while there is scientific evidence supporting the use of soy isoflavones for menopause, the effect size is modest and individual responses may vary. The evidence base justifies a moderate rating, reflecting both the quantity and mixed quality of available data.

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