Squaw Vine (Mitchella repens) has been traditionally used by Native American and early European settlers primarily as an aid for women's reproductive health, especially for preparing for childbirth. Its use for menopause is less directly documented, but it is sometimes included in modern herbal blends for menopause based on its general reputation as a “female tonic.” Historical herbal texts mention its use for menstrual irregularities and as a uterine tonic, but there is scant specific reference to menopause itself. The rationale appears to be based on its traditional applications for broader female reproductive concerns rather than clear evidence or targeted use for menopausal symptoms such as hot flashes or hormonal fluctuations.

Scientifically, there are no high-quality clinical trials or robust pharmacological studies that validate Squaw Vine’s effectiveness for menopause. The available evidence is limited to anecdotal reports and traditional knowledge. As such, the use of Squaw Vine for menopause is supported primarily by tradition, with very weak evidence for efficacy in this specific context.