Evidence supporting the use of: Vitamin D (cholecalciferol)
For the health condition: Menopause

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin D (cholecalciferol) is sometimes used as part of supportive therapy during menopause, primarily due to its established role in bone health. After menopause, decreased estrogen levels accelerate bone loss, increasing the risk for osteoporosis and fractures. Vitamin D is essential for calcium absorption and bone mineralization, and deficiency is linked to poorer bone health outcomes. Several clinical guidelines recommend ensuring adequate vitamin D intake (alongside calcium) for postmenopausal women to help prevent osteoporosis. However, evidence for vitamin D’s efficacy in directly treating other menopausal symptoms—such as hot flashes, mood disturbances, or genitourinary symptoms—is lacking.

Randomized controlled trials and meta-analyses have shown that while vitamin D supplementation can modestly improve bone mineral density in some populations, the effect on fracture prevention is mixed and often depends on baseline vitamin D status, calcium intake, and adherence to therapy. There is no substantial evidence that vitamin D alone improves core menopausal symptoms beyond its role in bone health. Thus, while its use is scientifically validated for bone support in postmenopausal women, its role in treating the wider spectrum of menopausal symptoms is not established.

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