Pentatropis capensis, also known as "Cow's Horn" or by other regional names, is a plant used in traditional medicine systems, particularly in parts of Africa and India. The use of Pentatropis capensis for menstrual irregularity is primarily rooted in traditional practices rather than modern scientific validation. Ethnobotanical surveys and local medicinal texts occasionally mention the plant as an ingredient in formulations aimed at addressing menstrual issues, such as irregular cycles, pain, or excessive bleeding. For example, some traditional healers and folk medicine practitioners believe that extracts from the leaves or other plant parts help regulate menstruation, possibly due to their perceived effects on the female reproductive system.

However, there is a distinct lack of clinical studies, pharmacological investigations, or published scientific evidence specifically evaluating the efficacy or mechanism of Pentatropis capensis in treating menstrual irregularity. Most available references are anecdotal or based on local knowledge, and there is little to no documentation in peer-reviewed scientific literature supporting its use for this purpose. Therefore, while the plant is traditionally used for menstrual irregularities, the scientific evidence for its effectiveness is minimal, and the evidence rating reflects the very limited support for this use.