Plectranthus amboinicus, also known as Indian borage or Cuban oregano, is traditionally used in various cultures for a range of medicinal purposes, including the management of menstrual irregularities. Ethnobotanical records and traditional medicine systems (such as Ayurveda and folk medicine in India, Southeast Asia, and Africa) cite its use for relieving menstrual cramps, regulating cycles, and addressing other gynecological concerns. The leaves are sometimes prepared as decoctions or infusions and administered to women experiencing irregular menstruation.

However, the evidence supporting these uses is based almost exclusively on traditional knowledge and anecdotal reports. There are currently no robust scientific studies, clinical trials, or pharmacological investigations that specifically validate the efficacy or safety of Plectranthus amboinicus for treating menstrual irregularity. The available scientific literature focuses more on its antimicrobial, anti-inflammatory, and antioxidant properties. Thus, while the plant is historically used for this indication, scientific substantiation is lacking, and the evidence rating remains low.