Evidence supporting the use of: Vitex Agnus-Castus
For the health condition: Menstrual Irregularity

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitex agnus-castus, also known as chaste tree or chasteberry, is traditionally used for menstrual irregularities, and this use has been the subject of several scientific studies. Its primary mechanism is believed to involve modulation of the hypothalamic-pituitary axis, particularly by influencing prolactin levels through dopaminergic activity. Elevated prolactin can disrupt normal menstrual cycles; Vitex appears to reduce prolactin secretion, which may help restore regular ovulatory cycles.

Clinical trials and systematic reviews provide moderate evidence of its efficacy. For example, a 2017 systematic review in Phytomedicine noted that Vitex may be effective for premenstrual syndrome (PMS) and some forms of menstrual irregularity, especially those related to luteal phase defects and hyperprolactinemia. However, the quality of studies varies, with some being small or lacking rigorous blinding. A 2013 Cochrane review concluded that while Vitex may improve symptoms, more high-quality research is needed for definitive conclusions regarding menstrual irregularity.

Overall, while traditional use is longstanding (dating back to ancient Greece), there is also a moderate and growing body of scientific evidence supporting its use for certain menstrual irregularities, particularly those associated with hormonal imbalances. Nonetheless, more rigorous, large-scale trials are required to clarify its efficacy and optimal use.

More about Vitex Agnus-Castus
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