Evidence supporting the use of: Kratom
For the health condition: Mental Illness

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Kratom (Mitragyna speciosa) has a history of traditional use in Southeast Asia primarily as a stimulant, analgesic, and remedy for opioid withdrawal, rather than specifically for mental illness. However, in recent years, kratom has gained popularity in Western countries for self-management of mood disorders such as anxiety and depression. The scientific evidence supporting its use in treating mental illness is limited and primarily consists of anecdotal reports, surveys, and small observational studies. Some users report improved mood, reduced anxiety, and relief from symptoms of depression when using kratom, which is attributed to its active alkaloids (mitragynine and 7-hydroxymitragynine) that interact with opioid and other neurotransmitter systems in the brain.

Despite these reports, controlled clinical trials evaluating kratom’s efficacy and safety for mental health conditions are lacking. Case reports and surveys also highlight potential risks, including dependence, withdrawal, and exacerbation of psychiatric symptoms in some individuals. Regulatory agencies, including the FDA, have raised concerns about safety and the lack of well-established therapeutic benefits. In summary, while there is some preliminary evidence and user testimony suggesting possible benefits for mood and anxiety disorders, the overall scientific evidence base remains weak (rated 2/5), and more rigorous research is needed to support its use for mental illness.

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Products containing Kratom

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