Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lion's mane mushroom (Hericium erinaceus) has gained attention for its potential benefits in supporting mental health, particularly for conditions such as depression, anxiety, and cognitive decline. The evidence base for its use is primarily preclinical and early-phase clinical research, rather than longstanding traditional use specifically for mental illness.

Several animal studies have shown that lion's mane extracts can promote neurogenesis (the growth of new neurons) and increase expression of nerve growth factor (NGF) in the brain, which is thought to be beneficial for cognitive function and possibly mood regulation. Some small-scale human clinical trials have reported reductions in symptoms of depression and anxiety in participants taking lion's mane supplements compared to placebo. For example, a 2010 double-blind study in women found reduced scores on measures of irritability and anxiety after four weeks of lion’s mane consumption.

However, the strength of the evidence is still considered low (rated 2/5) due to small sample sizes, short durations, and limited replication. The mechanisms by which lion’s mane could influence mental health—such as modulation of neurotrophic factors and anti-inflammatory effects—are biologically plausible but require further investigation. Lion’s mane is not a replacement for standard treatments, and more robust, large-scale randomized controlled trials are needed to confirm efficacy and safety for mental health conditions.

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