Evidence supporting the use of: Alpha-Lipoic Acid
For the health condition: Metabolic Syndrome

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Alpha-Lipoic Acid (ALA) is an antioxidant that has been investigated for its potential benefits in metabolic syndrome—a cluster of conditions that increase the risk of heart disease, stroke, and type 2 diabetes. Several clinical studies and meta-analyses suggest that ALA supplementation may improve certain aspects of metabolic syndrome, particularly by enhancing insulin sensitivity and improving glycemic control. For example, randomized controlled trials have shown that ALA can lower fasting blood glucose, reduce insulin resistance (as measured by HOMA-IR), and modestly decrease body weight in individuals with metabolic syndrome or related conditions such as type 2 diabetes and obesity.

Additionally, ALA has demonstrated potential to reduce markers of oxidative stress and inflammation, both of which contribute to the pathogenesis of metabolic syndrome. Some studies also report improvements in lipid profiles, including reductions in total cholesterol and triglycerides, though these effects appear to be less consistent.

However, the evidence is not uniformly strong. Many studies are small, short-term, or have methodological limitations. While ALA is not universally recommended in clinical guidelines for metabolic syndrome, the existing body of evidence provides moderate support for its adjunctive use, particularly for improving insulin sensitivity and glucose metabolism. Larger, high-quality trials are needed to confirm its long-term benefits and safety.

More about Alpha-Lipoic Acid
More about Metabolic Syndrome

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algal oil
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alpha-linolenic acid (ALA)
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anthocyanins
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bacillus subtilis
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beta-sitosterol
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bitter melon
black garlic
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butyrate triglyceride
campesterol
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canola oil
caterpillar mushroom
chia seed
chokeberry
chromium
cinnamon
conjugated linoleic acid (CLA)
turmeric
curcumin
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
flaxseed
fructooligosaccharides (FOS)
ginger
glucomannan
guar gum
hydroxycitric acid
inulin
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l-carnitine
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maitake mushroom
maqui berry
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naringin
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oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-7 fatty acids
omega-9 fatty acids
oyster mushroom
palmitoleic acid
quinoa
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resveratrol
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sardines
spirulina
tocotrienols
trans-pterostilbene
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vanadium
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vitamin C
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zinc
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Arjunolic acid
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chlorogenic acid
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Products containing Alpha-Lipoic Acid

We currently have no products on Vitabase that contain this ingredient.