Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Charantin is a bioactive compound isolated from bitter melon (Momordica charantia), a plant traditionally used in Asia, Africa, and South America for managing diabetes and related metabolic disturbances. Scientific interest in charantin stems from in vitro and animal studies demonstrating its potential hypoglycemic and antihyperlipidemic effects. Several preclinical studies have reported that charantin may enhance insulin secretion, improve glucose uptake in peripheral tissues, and modulate lipid metabolism, suggesting possible benefits in components of Metabolic Syndrome, such as hyperglycemia and dyslipidemia.

However, human clinical evidence remains limited. Some small-scale clinical trials using bitter melon extracts—of which charantin is one component—have shown modest improvements in blood glucose control, but these studies often lack rigorous methodology, and it is difficult to attribute observed effects specifically to charantin rather than other bitter melon constituents. Systematic reviews and meta-analyses generally conclude that while bitter melon shows promise for glycemic management, the quality of evidence is low and data specific to Metabolic Syndrome as a whole are insufficient.

In summary, while there is scientific rationale and some preclinical evidence for the use of charantin in supporting aspects of Metabolic Syndrome, robust human clinical trials are lacking. Thus, its use is supported by early scientific data, but the overall strength of evidence is weak.

More about charantin
More about Metabolic Syndrome

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7-hydroxymatairesinol (HMR)
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algal oil
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alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
alpha-lipoic acid
AMP-activated protein kinase (AMPK)
ampelopsin
anchovies
ankaflavin
anthocyanidins
anthocyanins
antirrhinin
Antrodia camphorata
apigenin
arabinoxylan
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Aronia melanocarpa
Ascophyllum nodosum
asparagus
astragaloside
Auricularia
avocado
bacillus subtilis
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berberine
beta-glucan
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beta-sitosterol
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black garlic
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blueberry
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campesterol
camu camu
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capsinoids
cardarine
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chia seed
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chlorogenic acid
chokeberry
chromium
cinnamon
conjugated linoleic acid (CLA)
corosolic acid
crocetin
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curcumin
cyanidin
cyanobacteria
cynaropicrin
Cystoseira canariensis
D-Pinitol
DHA (docosahexaenoic acid)
dihydrocapsiate
dihydrolipoic acid
diosgenin
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DPA (docosapentaenoic acid)
dragon fruit
Dunaliella
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epigallocatechin gallate (EGCG)
ergothioneine
evodiamine
fisetin
flavanols
flaxseed
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fructan
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fucosterol
fucoxanthin
galactooligosaccharides
garbanzo bean
ginger
Ginsenosides
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glucomannan
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guanidinopropionic acid (GPA )
guar gum
Guggulsterones
hydroxycitric acid
hydroxytyrosol
inulin
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isomaltulose
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oleanolic acid
oleic acid
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olive
omega-3 fatty acids
omega-7 fatty acids
omega-9 fatty acids
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oyster mushroom
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peanut
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phlorizin
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quinoa
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reishi mushroom
resveratrol
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Schizochytrium
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Sesamin
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spirulina
Sulforaphane
Syringic acid
Tagatose
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Tanshinone
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tocotrienols
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turmeric
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vitamin C
vitamin D
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Other health conditions supported by charantin

Cholesterol (high)
Diabetes
Metabolic Syndrome

Products containing charantin

We currently have no products on Vitabase that contain this ingredient.