Evidence supporting the use of: Chromium dinicotinate glycinate
For the health condition: Metabolic Syndrome
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Chromium dinicotinate glycinate is a complex of chromium, niacin (vitamin B3), and glycine, and is marketed as a nutritional supplement to support healthy glucose metabolism. Its use in metabolic syndrome is primarily based on the role of chromium in modulating insulin sensitivity and carbohydrate metabolism. Several small-scale clinical trials and animal studies have evaluated chromium supplementation (including chromium dinicotinate glycinate and other forms like chromium picolinate) for improving glycemic control and lipid profiles in individuals with metabolic syndrome or type 2 diabetes. Some studies have reported modest improvements in fasting blood glucose, insulin sensitivity, and lipid levels, but the results are inconsistent and often limited by methodological weaknesses, small sample sizes, or short durations. A 2014 systematic review and meta-analysis concluded that chromium supplementation may have a small beneficial effect on glycemic control, but the clinical significance is uncertain and not all forms of chromium are equally effective. Specifically, for chromium dinicotinate glycinate, there is limited direct evidence, with only a few trials suggesting potential benefit. Leading health authorities (such as the American Diabetes Association) do not currently recommend chromium supplementation for metabolic syndrome due to insufficient robust evidence. Thus, while the rationale for use is scientific, the quality and quantity of supporting evidence are low to moderate at best, justifying a rating of 2 out of 5.
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Other health conditions supported by Chromium dinicotinate glycinate
Cholesterol (high)Diabetes
Fat Metabolism (poor)
Metabolic Syndrome