Evidence supporting the use of: Conjugated Linolenic Acid
For the health condition: Metabolic Syndrome
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Conjugated Linolenic Acid (CLnA), a group of positional and geometric isomers of alpha-linolenic acid (ALA), has drawn scientific interest for its potential impact on metabolic syndrome. The reasoning is partly extrapolated from research on conjugated linoleic acid (CLA), which has shown some effects on body composition and lipid metabolism in animal and preliminary human studies. Limited in vitro and animal studies suggest that CLnA may exhibit anti-obesity, anti-diabetic, and lipid-lowering effects, likely due to modulation of lipid metabolism and anti-inflammatory pathways. For example, animal models have demonstrated that CLnA supplementation can reduce adiposity, improve insulin sensitivity, and modulate lipid profiles.
However, direct clinical evidence in humans with metabolic syndrome is sparse and inconclusive. Few small human trials have assessed CLnA supplementation, with mixed or negligible results on body weight, glucose metabolism, and blood lipids. Most clinical studies have focused on CLA rather than CLnA, and the metabolic effects of CLnA may not be identical. No major health agencies endorse CLnA for metabolic syndrome management.
In summary, while there is a scientific rationale and some preclinical support for the use of conjugated linolenic acid in metabolic syndrome, robust human evidence is lacking. The existing data justify only a low evidence rating. More well-designed human trials are needed to clarify its efficacy and safety for this indication.
More about Conjugated Linolenic Acid
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7-hydroxymatairesinol (HMR)7-Keto-DHEA
acai berry
akkermansia muciniphila
algal oil
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
anchovies
anthocyanins
asparagus
bacillus subtilis
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barley
berberine
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beta-sitosterol
bifidobacterium longum
bitter melon
black garlic
blueberry
brussel sprouts
butyrate triglyceride
campesterol
camu camu
canola oil
caterpillar mushroom
chia seed
chokeberry
chromium
cinnamon
conjugated linoleic acid (CLA)
turmeric
curcumin
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
flaxseed
fructooligosaccharides (FOS)
ginger
glucomannan
guar gum
hydroxycitric acid
inulin
krill oil
l-carnitine
lactobacillus helveticus
licorice root
mackerel
maitake mushroom
maqui berry
matcha
medium chain triglycerides (MCT)
moringa
naringin
nicotinamide riboside
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-7 fatty acids
omega-9 fatty acids
oyster mushroom
palmitoleic acid
quinoa
red yeast rice
reishi mushroom
resveratrol
rye
sardines
spirulina
tocotrienols
trans-pterostilbene
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vanadium
vanadyl sulfate
vitamin C
vitamin D
wheat grass
whey protein
xylooligosaccharides
zinc
β-nicotinamide mononucleotide (NMN)
algae
kidney beans
AMP-activated protein kinase (AMPK)
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15,16-Dihydrotanshinone I
12-methylcarnosic acid
3-desoxy-7-KETO-DHEA
4-hydroxyisoleucine
5,7-Dimethoxyflavone
6-Paradol
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Ankaflavin
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Ascophyllum nodosum
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Alpha-Lipoic Acid
Astragaloside
anthocyanidins
Ampelopsin
Alpha phytosterol
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alpha Methyl Tetradecylthioacetic Acid
Arjunolic acid
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Beta-hydroxybutyrate
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Cyanobacteria
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Cyanidin
chlorogenic acid
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corosolic acid
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peanut
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Other health conditions supported by Conjugated Linolenic Acid
Cancer (prevention)Inflammation
Metabolic Syndrome