Evidence supporting the use of: Dihydrolipoic Acid
For the health condition: Metabolic Syndrome
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Dihydrolipoic acid (DHLA) is the reduced form of alpha-lipoic acid (ALA), a compound that has been studied for its antioxidant properties and potential metabolic benefits. While most clinical research has focused on ALA rather than DHLA specifically, DHLA is believed to be the primary active intracellular form after ALA supplementation. Scientific studies indicate that ALA supplementation can improve aspects of Metabolic Syndrome, including insulin sensitivity, glucose metabolism, and markers of oxidative stress and inflammation. Several randomized controlled trials and meta-analyses have demonstrated that ALA (by extension, DHLA) may reduce fasting blood glucose, improve lipid profiles, and lower blood pressure in people with Metabolic Syndrome or related conditions such as type 2 diabetes.
The proposed mechanisms involve DHLA’s potent antioxidant effects, improvement of mitochondrial function, and modulation of cell signaling pathways involved in glucose uptake and lipid metabolism. However, direct evidence for DHLA itself (as opposed to ALA) in human studies is limited, and most available data reference the effects of ALA supplementation, with the assumption that its benefits are due to its conversion to DHLA in the body.
In summary, there is a scientific rationale and moderate clinical evidence for using ALA (and thereby DHLA) to support the management of Metabolic Syndrome, but more direct studies on DHLA are needed to strengthen the evidence base.
Other ingredients used for Metabolic Syndrome
7-hydroxymatairesinol (HMR)7-Keto-DHEA
acai berry
akkermansia muciniphila
algal oil
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
anchovies
anthocyanins
asparagus
bacillus subtilis
banaba
barley
berberine
Beta-Glucan
beta-sitosterol
bifidobacterium longum
bitter melon
black garlic
blueberry
brussel sprouts
butyrate triglyceride
campesterol
camu camu
canola oil
caterpillar mushroom
chia seed
chokeberry
chromium
cinnamon
conjugated linoleic acid (CLA)
turmeric
curcumin
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
flaxseed
fructooligosaccharides (FOS)
ginger
glucomannan
guar gum
hydroxycitric acid
inulin
krill oil
l-carnitine
lactobacillus helveticus
licorice root
mackerel
maitake mushroom
maqui berry
matcha
medium chain triglycerides (MCT)
moringa
naringin
nicotinamide riboside
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-7 fatty acids
omega-9 fatty acids
oyster mushroom
palmitoleic acid
quinoa
red yeast rice
reishi mushroom
resveratrol
rye
sardines
spirulina
tocotrienols
trans-pterostilbene
Urolithin A
vanadium
vanadyl sulfate
vitamin C
vitamin D
wheat grass
whey protein
xylooligosaccharides
zinc
β-nicotinamide mononucleotide (NMN)
algae
kidney beans
AMP-activated protein kinase (AMPK)
1-deoxynojirimycin
15,16-Dihydrotanshinone I
12-methylcarnosic acid
3-desoxy-7-KETO-DHEA
4-hydroxyisoleucine
5,7-Dimethoxyflavone
6-Paradol
Alpha Glucans
Ankaflavin
Apigenin
Aronia melanocarpa
Antrodia camphorata
Auricularia
Antirrhinin
Avocado
Ascophyllum nodosum
Acacetin
Alpha-Lipoic Acid
Astragaloside
anthocyanidins
Ampelopsin
Alpha phytosterol
Algal protein
Arabinoxylan
alpha Methyl Tetradecylthioacetic Acid
Arjunolic acid
Bifidobacterium adolescentis
Beta-hydroxybutyrate
Blakeslea trispora
Bean
Betanin
Brazil nut
Charantin
California chia
Cardarine
Cyanobacteria
Capsinoids
Cyanidin
chlorogenic acid
Capsiate
Chitin-Glucan Complex
Calanus finmarchicus
Crocetin
Cynaropicrin
Cystoseira canariensis
corosolic acid
Crypthecodinium
Carnosic acid
Docosahexaenoic Acid
Dunaliella
Dihydrocapsiate
Dragon Fruit
Dihydrolipoic Acid
D-Pinitol
Diosgenin
Ergothioneine
Ecklonia
peanut
Pistachio
Other health conditions supported by Dihydrolipoic Acid
Alzheimer's DiseaseDiabetes
Diabetic Retinopathy
Free Radical Damage
Metabolic Syndrome
Multiple Sclerosis
Peripheral Neuropathy