Evidence supporting the use of: Docosahexaenoic Acid
For the health condition: Metabolic Syndrome

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, has been investigated for its potential role in supporting metabolic syndrome, a cluster of conditions that increase the risk of heart disease, stroke, and type 2 diabetes. Scientific evidence suggests that DHA may have beneficial effects on several components of metabolic syndrome, particularly triglyceride levels, inflammation, and insulin sensitivity. Multiple randomized controlled trials and meta-analyses have shown that supplementation with DHA (often in combination with eicosapentaenoic acid, EPA) can significantly reduce serum triglyceride concentrations, a key metabolic syndrome marker. Some studies also report modest improvements in blood pressure and markers of inflammation, though the effects on fasting glucose, waist circumference, and HDL cholesterol are less consistent.

However, while the evidence supports a beneficial effect of DHA on some aspects of metabolic syndrome, especially hypertriglyceridemia, its impact on the syndrome as a whole is less well-established. Most studies examine DHA as part of a combined omega-3 intervention, making it difficult to attribute effects solely to DHA. Furthermore, the magnitude of benefit varies, and not all studies find significant improvements in all metabolic syndrome components. Clinical practice guidelines generally recommend omega-3 fatty acids for triglyceride lowering, not specifically for overall metabolic syndrome management. In summary, there is moderate scientific evidence supporting DHA's use for certain metabolic syndrome features, but data supporting a broad effect on the entire syndrome are still emerging.

More about docosahexaenoic Acid
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Products containing docosahexaenoic Acid

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