Evidence supporting the use of: Docosapentaenoic acid
For the health condition: Metabolic Syndrome
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Docosapentaenoic acid (DPA) is an omega-3 polyunsaturated fatty acid found in fish oils and certain marine organisms, and it is structurally related to the more widely studied eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Interest in DPA for metabolic syndrome is a relatively recent development, driven by its intermediate position in metabolic pathways and its occurrence in diets associated with cardiometabolic benefits. Some preclinical studies and limited human research suggest that DPA may help improve lipid profiles, reduce inflammation, and enhance endothelial function—mechanisms that are relevant in the context of metabolic syndrome, which is characterized by insulin resistance, dyslipidemia, hypertension, and central obesity. However, direct clinical evidence supporting DPA supplementation for the treatment or prevention of metabolic syndrome in humans is currently limited. Most human studies have focused on EPA and DHA, with DPA often grouped together or studied less specifically. A few observational studies and small intervention trials have noted correlations between higher circulating DPA levels and reduced risk of metabolic syndrome components, but these findings are not yet robust or consistent enough to warrant strong recommendations. As a result, the evidence base for DPA in metabolic syndrome can be considered preliminary, with a need for larger, well-controlled clinical trials to confirm its efficacy and establish optimal dosing. Thus, while there is scientific rationale and emerging evidence, the overall support remains moderate to weak at present.
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Other ingredients used for Metabolic Syndrome
7-hydroxymatairesinol (HMR)7-Keto-DHEA
acai berry
akkermansia muciniphila
algal oil
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
anchovies
anthocyanins
asparagus
bacillus subtilis
banaba
barley
berberine
Beta-Glucan
beta-sitosterol
bifidobacterium longum
bitter melon
black garlic
blueberry
brussel sprouts
butyrate triglyceride
campesterol
camu camu
canola oil
caterpillar mushroom
chia seed
chokeberry
chromium
cinnamon
conjugated linoleic acid (CLA)
turmeric
curcumin
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
flaxseed
fructooligosaccharides (FOS)
ginger
glucomannan
guar gum
hydroxycitric acid
inulin
krill oil
l-carnitine
lactobacillus helveticus
licorice root
mackerel
maitake mushroom
maqui berry
matcha
medium chain triglycerides (MCT)
moringa
naringin
nicotinamide riboside
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-7 fatty acids
omega-9 fatty acids
oyster mushroom
palmitoleic acid
quinoa
red yeast rice
reishi mushroom
resveratrol
rye
sardines
spirulina
tocotrienols
trans-pterostilbene
Urolithin A
vanadium
vanadyl sulfate
vitamin C
vitamin D
wheat grass
whey protein
xylooligosaccharides
zinc
β-nicotinamide mononucleotide (NMN)
algae
kidney beans
AMP-activated protein kinase (AMPK)
1-deoxynojirimycin
15,16-Dihydrotanshinone I
12-methylcarnosic acid
3-desoxy-7-KETO-DHEA
4-hydroxyisoleucine
5,7-Dimethoxyflavone
6-Paradol
Alpha Glucans
Ankaflavin
Apigenin
Aronia melanocarpa
Antrodia camphorata
Auricularia
Antirrhinin
Avocado
Ascophyllum nodosum
Acacetin
Alpha-Lipoic Acid
Astragaloside
anthocyanidins
Ampelopsin
Alpha phytosterol
Algal protein
Arabinoxylan
alpha Methyl Tetradecylthioacetic Acid
Arjunolic acid
Bifidobacterium adolescentis
Beta-hydroxybutyrate
Blakeslea trispora
Bean
Betanin
Brazil nut
Charantin
California chia
Cardarine
Cyanobacteria
Capsinoids
Cyanidin
chlorogenic acid
Capsiate
Chitin-Glucan Complex
Calanus finmarchicus
Crocetin
Cynaropicrin
Cystoseira canariensis
corosolic acid
Crypthecodinium
Carnosic acid
Docosahexaenoic Acid
Dunaliella
Dihydrocapsiate
Dragon Fruit
Dihydrolipoic Acid
D-Pinitol
Diosgenin
Ergothioneine
Ecklonia
peanut
Pistachio
Other health conditions supported by Docosapentaenoic acid
Alzheimer's DiseaseArthritis
Cardiovascular Disease
Cholesterol (high)
Depression
Inflammation
Inflammatory Bowel Disorders
Memory and Brain Function
Metabolic Syndrome
Psoriasis
Rheumatoid Arthritis
Triglycerides (high)