Evidence supporting the use of: Ergothioneine
For the health condition: Metabolic Syndrome

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ergothioneine, a naturally occurring amino acid and antioxidant found in mushrooms and some other foods, has generated scientific interest for its potential role in supporting metabolic health. While it is not a traditional or folk remedy for metabolic syndrome, recent preclinical and limited human studies suggest possible benefits. Metabolic syndrome is characterized by a cluster of conditions including insulin resistance, obesity, dyslipidemia, and hypertension, all of which are associated with increased oxidative stress and inflammation.

Ergothioneine’s primary mechanism of interest is its potent antioxidant and cytoprotective properties. Preclinical studies in cell cultures and animal models have demonstrated that ergothioneine can reduce oxidative stress, inhibit inflammatory pathways, and improve markers of metabolic health such as glucose and lipid metabolism. For example, some rodent studies have shown that ergothioneine supplementation can ameliorate insulin resistance and attenuate hepatic steatosis in models of diet-induced metabolic syndrome.

However, direct clinical evidence in humans is limited. Some observational studies have found correlations between higher blood ergothioneine levels and reduced incidence of cardiovascular diseases and mortality, but interventional trials specifically investigating its efficacy for metabolic syndrome are lacking as of 2024. Thus, while there is a scientific rationale and preclinical support for its use, robust human data are needed to confirm its effectiveness for treating or preventing metabolic syndrome.

More about ergothioneine
More about Metabolic Syndrome

Other ingredients used for Metabolic Syndrome

1-deoxynojirimycin
12-methylcarnosic acid
15,16-Dihydrotanshinone I
3-desoxy-7-KETO-DHEA
4-hydroxyisoleucine
5,7-Dimethoxyflavone
6-Paradol
7-hydroxymatairesinol (HMR)
7-Keto-DHEA
Acacetin
Acai berry
Akkermansia muciniphila
Algae
algal oil
Algal protein
Alpha Glucans
Alpha methyl tetradecylthioacetic acid
Alpha phytosterol
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
alpha-lipoic acid
AMP-activated protein kinase (AMPK)
ampelopsin
anchovies
ankaflavin
anthocyanidins
anthocyanins
antirrhinin
Antrodia camphorata
apigenin
arabinoxylan
Arjunolic acid
Aronia melanocarpa
Ascophyllum nodosum
asparagus
astragaloside
Auricularia
avocado
bacillus subtilis
banaba
barley
bean
berberine
beta-glucan
beta-hydroxybutyrate
beta-sitosterol
betanin
Bifidobacterium adolescentis
Bifidobacterium longum
black garlic
Blakeslea trispora
blueberry
Brazil nut
Brussel sprouts
butyrate triglyceride
Calanus finmarchicus
California chia
campesterol
camu camu
capsiate
capsinoids
cardarine
carnosic acid
caterpillar mushroom
charantin
chia seed
Chitin-Glucan Complex
chlorogenic acid
chokeberry
chromium
cinnamon
conjugated linoleic acid (CLA)
corosolic acid
crocetin
Crypthecodinium
curcumin
cyanidin
cyanobacteria
cynaropicrin
Cystoseira canariensis
D-Pinitol
DHA (docosahexaenoic acid)
dihydrocapsiate
dihydrolipoic acid
diosgenin
docosahexaenoic Acid
DPA (docosapentaenoic acid)
dragon fruit
Dunaliella
Ecklonia
epigallocatechin gallate (EGCG)
ergothioneine
evodiamine
fisetin
flavanols
flaxseed
Foxtail millet
fructan
fructooligosaccharides (FOS)
fucosterol
fucoxanthin
galactooligosaccharides
garbanzo bean
ginger
Ginsenosides
Glucan peptides
glucomannan
Glucoraphanin
Glucosinolates
guanidinopropionic acid (GPA )
guar gum
Guggulsterones
hydroxycitric acid
hydroxytyrosol
inulin
Irvingia gabonensis
Isoalantolactone
isomaltulose
Kamut
kidney beans
Konjac
krill oil
l-carnitine
Lactobacillus helveticus
Legume protein
Lentil
licorice root
lipstatin
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mangiferin
maqui berry
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medium chain triglycerides (MCT)
Momordicosides
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Moringa
Mulberroside A
Naringenin
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Neoeriocitrin
nicotinamide riboside
Nobiletin
oleanolic acid
oleic acid
Oleoylethanolamide
Oligosaccharides
olive
omega-3 fatty acids
omega-7 fatty acids
omega-9 fatty acids
oolong tea
oyster mushroom
Palatinose
palmitoleic acid
peanut
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phlorizin
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Pleurotus eryngii
polychitosamine
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quinoa
Rebaudioside
red yeast rice
reishi mushroom
resveratrol
rye
Salacia
Salidroside
Salmon Oil
Schizochytrium
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Sesamin
Sesamolin
Sinensetin
spirulina
Sulforaphane
Syringic acid
Tagatose
Tangeretin
Tanshinone
Tetradecylthioacetic acid
Theabrownin
Theaflavin
Thylakoid
tocotrienols
Trans-pterostilbene
turmeric
Tyrosol
Urolithin A
Vanadium
Vanadyl sulfate
vitamin C
vitamin D
wheat grass
Whey protein
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Products containing ergothioneine

We currently have no products on Vitabase that contain this ingredient.