Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Fisetin is a flavonoid polyphenol found in fruits and vegetables such as strawberries, apples, and onions. Its use for supporting or treating Metabolic Syndrome is primarily justified by emerging scientific evidence, rather than traditional medicinal use. Metabolic Syndrome is a cluster of conditions including insulin resistance, hypertension, dyslipidemia, and central obesity, all of which increase cardiovascular risk. Several preclinical studies have investigated fisetin’s effects on components of Metabolic Syndrome. In animal models, fisetin has demonstrated anti-inflammatory, antioxidant, and senolytic properties, which may contribute to improvements in insulin sensitivity, lipid profiles, and blood pressure regulation (Maher, 2018). Additionally, fisetin appears to modulate key pathways such as AMPK and SIRT1, which are involved in metabolic homeostasis. Some rodent studies report reduced adiposity and improved glucose tolerance following fisetin supplementation. However, high-quality human studies are lacking; most evidence comes from in vitro and animal research, and only a few small clinical trials have examined fisetin’s metabolic effects in humans. As such, while fisetin shows promise for metabolic health, current evidence is insufficient to fully endorse its use for Metabolic Syndrome in clinical practice. Further robust, large-scale human studies are needed to confirm efficacy and safety.

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