Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Licorice root (Glycyrrhiza glabra) has a long history of use in traditional medicine systems, but its application for Metabolic Syndrome is more recent and primarily supported by preliminary scientific studies rather than longstanding tradition. Some research suggests that licorice root and its active compound, glycyrrhizin, may impact factors associated with Metabolic Syndrome, such as obesity, insulin resistance, and dyslipidemia. For instance, small clinical trials and animal studies have indicated that licorice flavonoids may reduce body fat mass, improve lipid profiles, and exert anti-inflammatory effects—all relevant to Metabolic Syndrome. One study published in Obesity Research & Clinical Practice (2009) found that a licorice flavonoid oil supplement reduced total body fat and visceral fat in overweight individuals. Other laboratory studies have reported improved insulin sensitivity and reduced triglyceride levels following licorice supplementation.

However, the overall strength of the evidence is limited. Most studies are small, short-term, or conducted in animals, and results are not always consistent. Furthermore, licorice root can have significant side effects, such as increased blood pressure and disturbances in electrolyte balance, especially with long-term or high-dose use. Major guidelines do not recommend licorice root for Metabolic Syndrome due to insufficient robust clinical data and potential risks. In summary, while there is emerging scientific interest and some preliminary support for licorice root’s role in managing Metabolic Syndrome, the evidence is weak and does not justify routine use at this time.

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