Evidence supporting the use of: Omega-3 fatty acids
For the health condition: Metabolic Syndrome

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) found in fish oil, have significant scientific validation for their use in supporting and treating aspects of Metabolic Syndrome. Metabolic Syndrome is a cluster of conditions—including central obesity, dyslipidemia, hypertension, and insulin resistance—that increase the risk of cardiovascular disease and type 2 diabetes. Numerous randomized controlled trials and meta-analyses have demonstrated that omega-3 fatty acids can improve several metabolic parameters. Most notably, they are effective at lowering triglyceride levels, a key component of the dyslipidemia seen in Metabolic Syndrome. Some studies also show modest improvements in blood pressure and markers of inflammation. However, the effects on fasting blood glucose, insulin sensitivity, and HDL/LDL cholesterol ratios are less consistent.

The American Heart Association and other international guidelines endorse the use of omega-3 supplements for hypertriglyceridemia, which is often present in Metabolic Syndrome. While omega-3s are not a cure-all, their anti-inflammatory and lipid-lowering properties provide a mechanistic rationale for their use. Large-scale studies, such as the GISSI-Prevenzione and REDUCE-IT trials, support cardiovascular benefits particularly in high-risk individuals, though results are mixed for primary cardiovascular prevention. In summary, omega-3 fatty acids are scientifically validated as an adjunctive therapy for managing key components of Metabolic Syndrome, with the strongest evidence for triglyceride reduction.

More about omega-3 fatty acids
More about Metabolic Syndrome

Other ingredients used for Metabolic Syndrome

1-deoxynojirimycin
12-methylcarnosic acid
15,16-Dihydrotanshinone I
3-desoxy-7-KETO-DHEA
4-hydroxyisoleucine
5,7-Dimethoxyflavone
6-Paradol
7-hydroxymatairesinol (HMR)
7-Keto-DHEA
Acacetin
Acai berry
Akkermansia muciniphila
Algae
algal oil
Algal protein
Alpha Glucans
Alpha methyl tetradecylthioacetic acid
Alpha phytosterol
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
alpha-lipoic acid
AMP-activated protein kinase (AMPK)
ampelopsin
anchovies
ankaflavin
anthocyanidins
anthocyanins
antirrhinin
Antrodia camphorata
apigenin
arabinoxylan
Arjunolic acid
Aronia melanocarpa
Ascophyllum nodosum
asparagus
astragaloside
Auricularia
avocado
bacillus subtilis
banaba
barley
bean
berberine
beta-glucan
beta-hydroxybutyrate
beta-sitosterol
betanin
Bifidobacterium adolescentis
Bifidobacterium longum
black garlic
Blakeslea trispora
blueberry
Brazil nut
Brussel sprouts
butyrate triglyceride
Calanus finmarchicus
California chia
campesterol
camu camu
capsiate
capsinoids
cardarine
carnosic acid
caterpillar mushroom
charantin
chia seed
Chitin-Glucan Complex
chlorogenic acid
chokeberry
chromium
cinnamon
conjugated linoleic acid (CLA)
corosolic acid
crocetin
Crypthecodinium
curcumin
cyanidin
cyanobacteria
cynaropicrin
Cystoseira canariensis
D-Pinitol
DHA (docosahexaenoic acid)
dihydrocapsiate
dihydrolipoic acid
diosgenin
docosahexaenoic Acid
DPA (docosapentaenoic acid)
dragon fruit
Dunaliella
Ecklonia
epigallocatechin gallate (EGCG)
ergothioneine
evodiamine
fisetin
flavanols
flaxseed
Foxtail millet
fructan
fructooligosaccharides (FOS)
fucosterol
fucoxanthin
galactooligosaccharides
garbanzo bean
ginger
Ginsenosides
Glucan peptides
glucomannan
Glucoraphanin
Glucosinolates
guanidinopropionic acid (GPA )
guar gum
Guggulsterones
hydroxycitric acid
hydroxytyrosol
inulin
Irvingia gabonensis
Isoalantolactone
isomaltulose
Kamut
kidney beans
Konjac
krill oil
l-carnitine
Lactobacillus helveticus
Legume protein
Lentil
licorice root
lipstatin
lupin
maitake mushroom
mangiferin
maqui berry
Maslinic acid
Matcha
medium chain triglycerides (MCT)
Momordicosides
Monacolin
Monounsaturated fat
Moringa
Mulberroside A
Naringenin
Naringin
Neoeriocitrin
nicotinamide riboside
Nobiletin
oleanolic acid
oleic acid
Oleoylethanolamide
Oligosaccharides
olive
omega-3 fatty acids
omega-7 fatty acids
omega-9 fatty acids
oolong tea
oyster mushroom
Palatinose
palmitoleic acid
peanut
Phaeophyceae
phlorizin
Phycocyanin
Phytoplankton
Pinitol
Pistachio
Pleurotus eryngii
polychitosamine
Polydatin
polysaccharides
polyunsaturated fat
pu-er tea
punicalagins
punicalin
punicic acid
pyrroloquinoline quinone
quinoa
Rebaudioside
red yeast rice
reishi mushroom
resveratrol
rye
Salacia
Salidroside
Salmon Oil
Schizochytrium
Schizochytrium Oil
Sesamin
Sesamolin
Sinensetin
spirulina
Sulforaphane
Syringic acid
Tagatose
Tangeretin
Tanshinone
Tetradecylthioacetic acid
Theabrownin
Theaflavin
Thylakoid
tocotrienols
Trans-pterostilbene
turmeric
Tyrosol
Urolithin A
Vanadium
Vanadyl sulfate
vitamin C
vitamin D
wheat grass
Whey protein
Xanthohumol
xylooligosaccharides
Yacon
Zinc
β-nicotinamide mononucleotide (NMN)

Other health conditions supported by omega-3 fatty acids

Acne
Acquired Immune Deficiency Syndrome
Addictions (drugs)
Addictions (general remedies for)
Addictions (tobacco smoking or chewing)
Aging (prevention)
Alcoholism
Allergies (food)
Allergies (respiratory)
Alzheimer's Disease
Angina
Anorexia
Anxiety
Anxiety Disorders
Apathy
Arrhythmia
Arteriosclerosis
Anger (excessive)
Arthritis
Asthma
Athletic and Exercise Aids
Attention Deficit Disorder
Autism
Autoimmune Disorders
Backache
Bipolar Mood Disorder
Birth Defects (prevention)
Blood Clots (prevention of)
Bloodshot Eyes
Body Building
Broken Bones
Bulimia
Cancer (natural therapy for)
Cancer (prevention)
Cancer Treatment (reducing side effects)
Canker Sores
Cardiovascular Disease
Cartilage Damage
Cholesterol (high)
Cholesterol (low)
Chronic Obstructive Pulmonary Disorder
Circulation (poor)
Circulation (to the brain)
Concentration (poor)
Concussions
Confusion
Congestive Heart Failure
Dementia
Depression
Diabetes
Dysmenorrhea
Eczema
Emotional Sensitivity
Endometriosis
Epilepsy
Exercise
Eye Problems
Eyes (red or itching)
Eyesight (poor)
Fat Metabolism (poor)
Fatigue
Fatty Liver Disease
Fibrosis
Free Radical Damage
Glaucoma
Gout
Hair (loss or thinning)
Hair Care (general)
Hashimoto's Disease
Hearing Loss
Heart (weakness)
Heart Fibrillation or Palpitations
Hepatitis
Hypertension
Infertility
Inflammation
Inflammatory Bowel Disorders
Irritability
Lou Gehrig's Disease
Lupus
Macular Degeneration
Memory and Brain Function
Menopause
Metabolic Syndrome
Migraine
Muscular Dystrophy
Nerve Damage
Neuralgia and Neuritis
Numbness
Osteoporosis
Parkinson's Disease
Peripheral Neuropathy
Pets (supplements for)
PMS Type D
PMS Type P
PMS Type S
Polyps
Post Partum Depression
Post Partum Weakness
Pregnancy (herbs and supplements for)
Psoriasis
Raynaud's Disease
Rheumatoid Arthritis
Rosacea
Schizophrenia
Seasonal Affective Disorder
Seborrhea
Seizures
Senility
Sickle Cell Anemia
Skin (dry and/or flaky)
Skin Care (general)
Spinal Disks
Strokes
Surgery (healing from)
Surgery (preparation for)
Thinking (cloudy)
Thrombosis
Triglycerides (high)
Triglycerides (low)
Vaginal Dryness