Evidence supporting the use of: Pentacyclic Oxindole Alkaloids
For the health condition: Metabolic Syndrome

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Pentacyclic oxindole alkaloids (POAs) are a class of compounds primarily found in the medicinal plant Uncaria tomentosa (Cat’s Claw). While Cat’s Claw has a long history of traditional use for inflammatory and immune-related conditions, its application for metabolic syndrome is a developing area of scientific inquiry rather than traditional medicine. Recent preclinical studies have suggested that POAs possess anti-inflammatory and antioxidant properties, which are relevant to the pathophysiology of metabolic syndrome—a cluster of conditions including insulin resistance, hypertension, dyslipidemia, and central obesity. For example, some animal studies have indicated that extracts containing POAs may improve insulin sensitivity, modulate lipid profiles, and reduce markers of systemic inflammation and oxidative stress, all of which are significant in metabolic syndrome. However, clinical trials in humans are sparse and generally of low quality, with small sample sizes and limited endpoints directly related to metabolic syndrome. Most available data are extrapolated from broader studies on inflammation or cardiovascular risk factors. As such, while there is some scientific rationale and early preclinical evidence to support the use of POAs for metabolic syndrome, robust clinical validation is lacking. Therefore, the evidence for their use in this context remains preliminary and should be interpreted with caution.

More about Pentacyclic Oxindole Alkaloids
More about Metabolic Syndrome

Other ingredients used for Metabolic Syndrome

7-hydroxymatairesinol (HMR)
7-Keto-DHEA
acai berry
akkermansia muciniphila
algal oil
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
anchovies
anthocyanins
asparagus
bacillus subtilis
banaba
barley
berberine
Beta-Glucan
beta-sitosterol
bifidobacterium longum
bitter melon
black garlic
blueberry
brussel sprouts
butyrate triglyceride
campesterol
camu camu
canola oil
caterpillar mushroom
chia seed
chokeberry
chromium
cinnamon
conjugated linoleic acid (CLA)
turmeric
curcumin
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
flaxseed
fructooligosaccharides (FOS)
ginger
glucomannan
guar gum
hydroxycitric acid
inulin
krill oil
l-carnitine
lactobacillus helveticus
licorice root
mackerel
maitake mushroom
maqui berry
matcha
medium chain triglycerides (MCT)
moringa
naringin
nicotinamide riboside
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-7 fatty acids
omega-9 fatty acids
oyster mushroom
palmitoleic acid
quinoa
red yeast rice
reishi mushroom
resveratrol
rye
sardines
spirulina
tocotrienols
trans-pterostilbene
Urolithin A
vanadium
vanadyl sulfate
vitamin C
vitamin D
wheat grass
whey protein
xylooligosaccharides
zinc
β-nicotinamide mononucleotide (NMN)
algae
kidney beans
AMP-activated protein kinase (AMPK)
1-deoxynojirimycin
15,16-Dihydrotanshinone I
12-methylcarnosic acid
3-desoxy-7-KETO-DHEA
4-hydroxyisoleucine
5,7-Dimethoxyflavone
6-Paradol
Alpha Glucans
Ankaflavin
Apigenin
Aronia melanocarpa
Antrodia camphorata
Auricularia
Antirrhinin
Avocado
Ascophyllum nodosum
Acacetin
Alpha-Lipoic Acid
Astragaloside
anthocyanidins
Ampelopsin
Alpha phytosterol
Algal protein
Arabinoxylan
alpha Methyl Tetradecylthioacetic Acid
Arjunolic acid
Bifidobacterium adolescentis
Beta-hydroxybutyrate
Blakeslea trispora
Bean
Betanin
Brazil nut
Charantin
California chia
Cardarine
Cyanobacteria
Capsinoids
Cyanidin
chlorogenic acid
Capsiate
Chitin-Glucan Complex
Calanus finmarchicus
Crocetin
Cynaropicrin
Cystoseira canariensis
corosolic acid
Crypthecodinium
Carnosic acid
Docosahexaenoic Acid
Dunaliella
Dihydrocapsiate
Dragon Fruit
Dihydrolipoic Acid
D-Pinitol
Diosgenin
Ergothioneine
Ecklonia
peanut
Pistachio

Products containing Pentacyclic Oxindole Alkaloids

We currently have no products on Vitabase that contain this ingredient.