Evidence supporting the use of: Pyrroloquinoline Quinone
For the health condition: Metabolic Syndrome

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Pyrroloquinoline quinone (PQQ) is a redox cofactor and antioxidant that has attracted attention for its potential metabolic benefits, including applications in metabolic syndrome. The scientific evidence supporting PQQ's use for metabolic syndrome is limited but emerging, mostly from preclinical studies and a handful of small human trials.

Animal studies have shown that PQQ supplementation can improve markers of metabolic health, such as lowering blood glucose, improving lipid profiles, and reducing markers of oxidative stress and inflammation—factors relevant for metabolic syndrome. For example, rodent models have demonstrated that PQQ may enhance mitochondrial biogenesis and improve insulin sensitivity. These mechanistic insights suggest a plausible benefit for metabolic syndrome.

In humans, clinical evidence is sparse. A few small-scale studies (e.g., Harris et al., 2013, "Nutritional Supplementation with PQQ Modulates Fatty Acid Metabolism in Humans") have reported modest improvements in markers like plasma triglycerides and reduced inflammation after PQQ supplementation. However, these studies often have small sample sizes, short durations, and do not focus exclusively on patients with metabolic syndrome. There are currently no large, well-powered randomized controlled trials (RCTs) directly assessing PQQ's effectiveness for metabolic syndrome.

In summary, the use of PQQ for metabolic syndrome is supported by preliminary animal and in vitro research, and limited early human data, but lacks robust clinical validation. Therefore, the evidence rating is 2 out of 5.

More about Pyrroloquinoline Quinone
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Products containing Pyrroloquinoline Quinone

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