Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Resveratrol, a polyphenolic compound found in grapes, red wine, and some berries, has garnered scientific interest for its potential benefits in addressing Metabolic Syndrome (MetS), a cluster of conditions including insulin resistance, hypertension, dyslipidemia, and obesity. The use of resveratrol for MetS is justified by preliminary scientific studies rather than by traditional medicine, as its identification and isolation are relatively modern, and traditional uses of the specific compound are largely absent.

Preclinical studies in animal models and cell cultures suggest that resveratrol may improve insulin sensitivity, reduce inflammation, and modulate lipid metabolism, possibly via activation of SIRT1 and AMPK pathways. Some small-scale human clinical trials have shown modest improvements in glucose control, blood pressure, and lipid profiles when resveratrol is supplemented, particularly in populations at risk for or diagnosed with MetS. However, the results are inconsistent, dosages vary widely, and the bioavailability of resveratrol in humans is low, limiting its clinical applicability.

Meta-analyses of randomized controlled trials indicate only minor or inconsistent benefits for core MetS parameters, and larger, longer-term studies are lacking. While the biological plausibility is strong and early results are promising, the current scientific evidence is not robust or consistent enough to recommend resveratrol as a primary therapy for MetS. Its use is best considered as experimental or adjunctive, pending further research.

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Other ingredients used for Metabolic Syndrome

Other health conditions supported by resveratrol

Products containing resveratrol

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