Evidence supporting the use of: Salidroside
For the health condition: Metabolic Syndrome

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Salidroside, a bioactive compound found in Rhodiola rosea, has been investigated for its potential to support or treat Metabolic Syndrome (MetS). Preclinical studies (cellular and animal models) suggest salidroside may improve insulin sensitivity, reduce blood glucose levels, ameliorate lipid profiles, and mitigate oxidative stress and inflammation—key factors underlying MetS. For example, several rodent studies have reported that salidroside supplementation leads to reduced body weight, improved glucose tolerance, decreased triglycerides, and lower inflammatory markers. Mechanistically, salidroside appears to modulate pathways such as AMPK activation and the inhibition of NF-κB signaling.

However, robust clinical evidence in humans is lacking. Most available data come from laboratory or animal experiments, and only a handful of small-scale human studies or trials of Rhodiola rosea (where salidroside is just one of many constituents) exist. The translation of these preclinical findings to humans remains uncertain. Systematic reviews and meta-analyses consistently highlight the need for well-designed clinical trials to determine efficacy and safety for metabolic health outcomes.

In summary, while there is scientific interest and promising preclinical evidence for salidroside’s role in managing Metabolic Syndrome, current human data are insufficient. Its use for this purpose is therefore supported by limited scientific validation, justifying a moderate-low evidence rating.

More about Salidroside
More about Metabolic Syndrome

Other ingredients used for Metabolic Syndrome

7-hydroxymatairesinol (HMR)
7-Keto-DHEA
acai berry
akkermansia muciniphila
algal oil
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
anchovies
anthocyanins
asparagus
bacillus subtilis
banaba
barley
berberine
Beta-Glucan
beta-sitosterol
bifidobacterium longum
bitter melon
black garlic
blueberry
brussel sprouts
butyrate triglyceride
campesterol
camu camu
canola oil
caterpillar mushroom
chia seed
chokeberry
chromium
cinnamon
conjugated linoleic acid (CLA)
turmeric
curcumin
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
flaxseed
fructooligosaccharides (FOS)
ginger
glucomannan
guar gum
hydroxycitric acid
inulin
krill oil
l-carnitine
lactobacillus helveticus
licorice root
mackerel
maitake mushroom
maqui berry
matcha
medium chain triglycerides (MCT)
moringa
naringin
nicotinamide riboside
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-7 fatty acids
omega-9 fatty acids
oyster mushroom
palmitoleic acid
quinoa
red yeast rice
reishi mushroom
resveratrol
rye
sardines
spirulina
tocotrienols
trans-pterostilbene
Urolithin A
vanadium
vanadyl sulfate
vitamin C
vitamin D
wheat grass
whey protein
xylooligosaccharides
zinc
β-nicotinamide mononucleotide (NMN)
algae
kidney beans
AMP-activated protein kinase (AMPK)
1-deoxynojirimycin
15,16-Dihydrotanshinone I
12-methylcarnosic acid
3-desoxy-7-KETO-DHEA
4-hydroxyisoleucine
5,7-Dimethoxyflavone
6-Paradol
Alpha Glucans
Ankaflavin
Apigenin
Aronia melanocarpa
Antrodia camphorata
Auricularia
Antirrhinin
Avocado
Ascophyllum nodosum
Acacetin
Alpha-Lipoic Acid
Astragaloside
anthocyanidins
Ampelopsin
Alpha phytosterol
Algal protein
Arabinoxylan
alpha Methyl Tetradecylthioacetic Acid
Arjunolic acid
Bifidobacterium adolescentis
Beta-hydroxybutyrate
Blakeslea trispora
Bean
Betanin
Brazil nut
Charantin
California chia
Cardarine
Cyanobacteria
Capsinoids
Cyanidin
chlorogenic acid
Capsiate
Chitin-Glucan Complex
Calanus finmarchicus
Crocetin
Cynaropicrin
Cystoseira canariensis
corosolic acid
Crypthecodinium
Carnosic acid
Docosahexaenoic Acid
Dunaliella
Dihydrocapsiate
Dragon Fruit
Dihydrolipoic Acid
D-Pinitol
Diosgenin
Ergothioneine
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peanut
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Products containing Salidroside

We currently have no products on Vitabase that contain this ingredient.