Syringic acid is a naturally occurring phenolic compound found in various plants, fruits, and vegetables. Its use in relation to metabolic syndrome is primarily supported by preclinical scientific studies, rather than established traditional medical practices. Several animal and in vitro studies have indicated that syringic acid may exhibit beneficial effects on components of metabolic syndrome, such as hyperglycemia, dyslipidemia, and oxidative stress. For example, syringic acid has been shown to improve insulin sensitivity, reduce blood glucose levels, and modulate lipid profiles in rodent models of diabetes and high-fat diet-induced metabolic disturbances. The mechanisms proposed include antioxidant activity, inhibition of inflammatory pathways, and regulation of key metabolic enzymes.

However, it is important to note that, as of June 2024, there is a lack of robust clinical data in humans to confirm these effects. Most evidence is limited to laboratory and animal research, and no well-designed clinical trials have been conducted to establish the safety and efficacy of syringic acid for managing metabolic syndrome in humans. Therefore, while scientific exploration is ongoing and the preclinical data are promising, the overall evidence remains preliminary. Health professionals do not currently recommend syringic acid as a standard treatment or supportive agent for metabolic syndrome based on available research.