Evidence supporting the use of: Tetradecylthioacetic acid
For the health condition: Metabolic Syndrome
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Tetradecylthioacetic Acid (TTA) and Metabolic Syndrome: Evidence Overview
Tetradecylthioacetic acid (TTA) is a synthetic fatty acid analogue that has been investigated for its metabolic effects, particularly on lipid metabolism and insulin sensitivity. Unlike many supplements, TTA’s proposed use for metabolic syndrome is not based on traditional or folk medicine but rather on preclinical and clinical scientific research.
Preclinical Evidence: In animal studies, TTA has demonstrated the ability to modulate lipid metabolism, reduce hepatic fat accumulation, and improve insulin sensitivity. It acts as a peroxisome proliferator-activated receptor (PPAR) agonist, mainly influencing PPARα and to a lesser extent PPARγ, which are nuclear receptors involved in the regulation of fatty acid oxidation and glucose metabolism.
Human Studies: Clinical evidence is limited but does exist. Small human trials (e.g., Madsen et al., 2008, and subsequent studies) have shown that TTA supplementation can reduce plasma triglyceride levels and markers of inflammation in patients with type 2 diabetes or metabolic syndrome. However, these studies often have small sample sizes and short durations, and improvements in glucose control or other central features of metabolic syndrome are inconsistent.
Conclusion: While there is a scientific rationale and some early clinical evidence supporting TTA’s use for metabolic syndrome—mainly for lipid lowering—the evidence base is modest and not yet robust enough for widespread clinical recommendation. Larger, longer-term human trials are needed to confirm efficacy and safety.
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Other health conditions supported by Tetradecylthioacetic acid
Cholesterol (high)Fat Metabolism (poor)
Fatty Liver Disease
Metabolic Syndrome
Triglycerides (high)