Evidence supporting the use of: 1,3,7-Trimethylpurine-2,6-dione
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

1,3,7-Trimethylpurine-2,6-dione is the chemical name for caffeine. Its use in the treatment or support of migraine is scientifically validated and is included in several evidence-based clinical guidelines. Multiple clinical studies have demonstrated that caffeine, when used in combination with common analgesics such as acetaminophen or aspirin, can enhance their efficacy in relieving migraine attacks. The mechanism involves caffeine's antagonism of adenosine receptors, leading to vasoconstriction of cerebral blood vessels, which can counteract the vasodilation associated with migraine headaches. Additionally, caffeine’s ability to increase the absorption and potency of certain pain medications contributes to its therapeutic effect.

Several over-the-counter and prescription migraine medications (e.g., Excedrin Migraine) contain caffeine for this reason. The American Headache Society and other professional organizations recognize caffeine as an effective adjunct in the acute treatment of migraine. However, it is worth noting that excessive or chronic use of caffeine can lead to medication overuse headache or withdrawal headache in some individuals. Thus, while there is robust scientific evidence for its use as an acute migraine treatment, guidelines typically recommend moderation and caution against chronic daily use.

In summary, caffeine’s role in migraine management is well-supported by scientific literature, primarily as an adjuvant to analgesics for acute relief, rather than as a standalone or preventive therapy.

More about 1,3,7-Trimethylpurine-2,6-dione
More about Migraine

Other ingredients used for Migraine

1,3,7-Trimethylpurine-2,6-dione
5-Hydroxytryptophan (5-HTP)
5-methyltetrahydrofolate glucosamine
Albizia
Almond fruit
alpha-linolenic acid (ALA)
alpha-lipoic acid
apple cider vinegar
ashwagandha
atractylodes
atractylone
Baikal Skullcap
balsam
banyan
bergamot
beta caryophyllene
beta-hydroxybutyrate
betony
Bifidobacteria
Black Hellebore
black seed
black tea
blackboard tree
Blepharis
brahmi
bupleurum falcatum
butterbur
cannabidiol
Carthamus
Chinese salvia root
Chinese silkvine
chrysanthemum
coenzyme Q10 (CoQ10)
cola nut
Corydalis
creatine
crocin
curcumin
danshen
DHA (docosahexaenoic acid)
docosahexaenoic Acid
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
feverfew
Ficus religiosa
Ficus simplicissima
fish
fish oil
flavanones
flavin mononucleotide
folic acid
frankincense
Gelsemium
ginger
ginkgo biloba
ginkgolides
Ginkgoside
goldthread
gooseberry
gotu kola
Hellebore
Indian frankincense
iridoids
ketone salts
kuding tea
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
lemon balm
Lesser speargrass
linalool
little ironweed
luteolin
magnesium
Meadowsweet
Melatonin
Mesua
Methylxanthine
Moringa
Nardostachys
Niacin (vitamin B3)
Night jessamine
omega-3 fatty acids
Osthole
paeoniflorin
Palmitoylethanolamide (PEA)
Peppermint
Petasines
Phthalides
phytocannabinoids
pine bark
Polygonum
Puerarin
purple butterbur root
Pycnogenol
Rauvolfia
riboflavin (vitamin B2)
Rubiaceae
Rubus
rue
Salmon Oil
Sandalwood
Scabrous Gentian
Sensitive Plant
soursop
specialized pro-resolving mediators (SPMs)
Spikenard
Swertia
Szechuan lovage
turmeric
ubiquinol
Uncaria
Valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
Withanolides
Xanthine
Xanthone
Xanthophyll
Yuzu
Zinc
Zingerone

Products containing 1,3,7-Trimethylpurine-2,6-dione

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