Evidence supporting the use of: 1,3,7-Trimethylpurine-2,6-dione
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

1,3,7-Trimethylpurine-2,6-dione is the chemical name for caffeine. Its use in the treatment or support of migraine is scientifically validated and is included in several evidence-based clinical guidelines. Multiple clinical studies have demonstrated that caffeine, when used in combination with common analgesics such as acetaminophen or aspirin, can enhance their efficacy in relieving migraine attacks. The mechanism involves caffeine's antagonism of adenosine receptors, leading to vasoconstriction of cerebral blood vessels, which can counteract the vasodilation associated with migraine headaches. Additionally, caffeine’s ability to increase the absorption and potency of certain pain medications contributes to its therapeutic effect.

Several over-the-counter and prescription migraine medications (e.g., Excedrin Migraine) contain caffeine for this reason. The American Headache Society and other professional organizations recognize caffeine as an effective adjunct in the acute treatment of migraine. However, it is worth noting that excessive or chronic use of caffeine can lead to medication overuse headache or withdrawal headache in some individuals. Thus, while there is robust scientific evidence for its use as an acute migraine treatment, guidelines typically recommend moderation and caution against chronic daily use.

In summary, caffeine’s role in migraine management is well-supported by scientific literature, primarily as an adjuvant to analgesics for acute relief, rather than as a standalone or preventive therapy.

More about 1,3,7-Trimethylpurine-2,6-dione
More about Migraine

Other ingredients used for Migraine

5-Hydroxytryptophan (5-HTP)
alpha-linolenic acid (ALA)
ashwagandha
bergamot
beta caryophyllene
black tea
Indian frankincense
bupleurum falcatum
Chinese salvia root
coenzyme Q10 (CoQ10)
turmeric
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
feverfew
fish oil
ginger
ginkgo biloba
gooseberry
gotu kola
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
luteolin
magnesium
melatonin
moringa
niacin (vitamin B3)
omega-3 fatty acids
Peppermint
phytocannabinoids
pine bark
purple butterbur root
riboflavin (vitamin B2)
specialized pro-resolving mediators (SPMs)
Almond fruit
ubiquinol
valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
zinc
atractylodes
blackboard tree
swertia
Szechuan lovage
chrysanthemum
soursop
1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
Apple Cider Vinegar
Albizia
Alpha-Lipoic Acid
Atractylone
Betony
Black Seed
Baikal Skullcap
Beta-hydroxybutyrate
Blepharis
Balsam
Banyan
Brahmi
Butterbur
Bifidobacteria
Black Hellebore
Chinese Silkvine
Crocin
Creatine
Cannabidiol
Corydalis
Carthamus
cola nut
Docosahexaenoic Acid
Danshen
Eicosapentaenoic Acid
Folic Acid
Flavin mononucleotide
Ficus religiosa
Fish
Flavanones
Ficus simplicissima
Frankincense
Goldthread
Gelsemium
Ginkgolides
Ginkgoside
Hellebore
iridoids
Ketone Salts
Kuding tea
lemon balm
Lesser speargrass
Little ironweed
Linalool
Mesua
Methylxanthine
Meadowsweet
Nardostachys
Night jessamine
Osthole
Puerarin
Petasines
Phthalides
Paeoniflorin
Pycnogenol
Polygonum
Palmitoylethanolamide (PEA)
Rue
Rubus
Rauvolfia
Rubiaceae
Spikenard
Sensitive Plant
Salmon Oil
Sandalwood
Scabrous Gentian
Uncaria
Withanolides
Xanthine
Xanthophyll
Xanthone
Yuzu
Zingerone

Products containing 1,3,7-Trimethylpurine-2,6-dione

We currently have no products on Vitabase that contain this ingredient.