Evidence supporting the use of: 5-methyltetrahydrofolate glucosamine
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

5-methyltetrahydrofolate (5-MTHF) is the biologically active form of folate, and the glucosamine salt is one of its stable supplemental forms. The rationale for using 5-MTHF to support or treat migraine primarily derives from its role in homocysteine metabolism. Elevated homocysteine levels have been observed in some individuals with migraine, particularly migraine with aura, and there is evidence that certain genetic polymorphisms (such as MTHFR C677T) may impair folate metabolism, leading to higher homocysteine and potentially increased migraine risk or severity.

A few small clinical trials have investigated the use of folate (often in combination with vitamins B6 and B12) to reduce migraine frequency and severity, especially in patients with elevated homocysteine or MTHFR mutations. For example, a 2009 randomized controlled trial (Lea et al., Pharmacogenet Genomics) found that supplementation with folate, B6, and B12 reduced homocysteine and improved migraine symptoms in a subgroup of patients. However, studies specifically using 5-MTHF glucosamine are limited, and most research uses folic acid or unspecified forms of folate.

Overall, there is preliminary scientific support for the idea that folate supplementation may help some migraine sufferers, particularly those with specific genetic backgrounds. However, the evidence base is modest, and direct evidence for 5-MTHF glucosamine as a migraine intervention is limited. Larger and more definitive trials are needed to clarify its efficacy and optimal use.

More about 5-methyltetrahydrofolate glucosamine
More about Migraine

Other ingredients used for Migraine

5-Hydroxytryptophan (5-HTP)
alpha-linolenic acid (ALA)
ashwagandha
bergamot
beta caryophyllene
black tea
Indian frankincense
bupleurum falcatum
Chinese salvia root
coenzyme Q10 (CoQ10)
turmeric
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
feverfew
fish oil
ginger
ginkgo biloba
gooseberry
gotu kola
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
luteolin
magnesium
melatonin
moringa
niacin (vitamin B3)
omega-3 fatty acids
Peppermint
phytocannabinoids
pine bark
purple butterbur root
riboflavin (vitamin B2)
specialized pro-resolving mediators (SPMs)
Almond fruit
ubiquinol
valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
zinc
atractylodes
blackboard tree
swertia
Szechuan lovage
chrysanthemum
soursop
1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
Apple Cider Vinegar
Albizia
Alpha-Lipoic Acid
Atractylone
Betony
Black Seed
Baikal Skullcap
Beta-hydroxybutyrate
Blepharis
Balsam
Banyan
Brahmi
Butterbur
Bifidobacteria
Black Hellebore
Chinese Silkvine
Crocin
Creatine
Cannabidiol
Corydalis
Carthamus
cola nut
Docosahexaenoic Acid
Danshen
Eicosapentaenoic Acid
Folic Acid
Flavin mononucleotide
Ficus religiosa
Fish
Flavanones
Ficus simplicissima
Frankincense
Goldthread
Gelsemium
Ginkgolides
Ginkgoside
Hellebore
iridoids
Ketone Salts
Kuding tea
lemon balm
Lesser speargrass
Little ironweed
Linalool
Mesua
Methylxanthine
Meadowsweet
Nardostachys
Night jessamine
Osthole
Puerarin
Petasines
Phthalides
Paeoniflorin
Pycnogenol
Polygonum
Palmitoylethanolamide (PEA)
Rue
Rubus
Rauvolfia
Rubiaceae
Spikenard
Sensitive Plant
Salmon Oil
Sandalwood
Scabrous Gentian
Uncaria
Withanolides
Xanthine
Xanthophyll
Xanthone
Yuzu
Zingerone

Products containing 5-methyltetrahydrofolate glucosamine

We currently have no products on Vitabase that contain this ingredient.