Evidence supporting the use of: 5-methyltetrahydrofolate glucosamine
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

5-methyltetrahydrofolate (5-MTHF) is the biologically active form of folate, and the glucosamine salt is one of its stable supplemental forms. The rationale for using 5-MTHF to support or treat migraine primarily derives from its role in homocysteine metabolism. Elevated homocysteine levels have been observed in some individuals with migraine, particularly migraine with aura, and there is evidence that certain genetic polymorphisms (such as MTHFR C677T) may impair folate metabolism, leading to higher homocysteine and potentially increased migraine risk or severity.

A few small clinical trials have investigated the use of folate (often in combination with vitamins B6 and B12) to reduce migraine frequency and severity, especially in patients with elevated homocysteine or MTHFR mutations. For example, a 2009 randomized controlled trial (Lea et al., Pharmacogenet Genomics) found that supplementation with folate, B6, and B12 reduced homocysteine and improved migraine symptoms in a subgroup of patients. However, studies specifically using 5-MTHF glucosamine are limited, and most research uses folic acid or unspecified forms of folate.

Overall, there is preliminary scientific support for the idea that folate supplementation may help some migraine sufferers, particularly those with specific genetic backgrounds. However, the evidence base is modest, and direct evidence for 5-MTHF glucosamine as a migraine intervention is limited. Larger and more definitive trials are needed to clarify its efficacy and optimal use.

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