Evidence supporting the use of: 5-methyltetrahydrofolate glucosamine
For the health condition: Migraine

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

5-methyltetrahydrofolate (5-MTHF) is the biologically active form of folate, and the glucosamine salt is one of its stable supplemental forms. The rationale for using 5-MTHF to support or treat migraine primarily derives from its role in homocysteine metabolism. Elevated homocysteine levels have been observed in some individuals with migraine, particularly migraine with aura, and there is evidence that certain genetic polymorphisms (such as MTHFR C677T) may impair folate metabolism, leading to higher homocysteine and potentially increased migraine risk or severity.

A few small clinical trials have investigated the use of folate (often in combination with vitamins B6 and B12) to reduce migraine frequency and severity, especially in patients with elevated homocysteine or MTHFR mutations. For example, a 2009 randomized controlled trial (Lea et al., Pharmacogenet Genomics) found that supplementation with folate, B6, and B12 reduced homocysteine and improved migraine symptoms in a subgroup of patients. However, studies specifically using 5-MTHF glucosamine are limited, and most research uses folic acid or unspecified forms of folate.

Overall, there is preliminary scientific support for the idea that folate supplementation may help some migraine sufferers, particularly those with specific genetic backgrounds. However, the evidence base is modest, and direct evidence for 5-MTHF glucosamine as a migraine intervention is limited. Larger and more definitive trials are needed to clarify its efficacy and optimal use.

More about 5-methyltetrahydrofolate glucosamine
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Other ingredients used for Migraine

1,3,7-Trimethylpurine-2,6-dione
5-Hydroxytryptophan (5-HTP)
5-methyltetrahydrofolate glucosamine
Albizia
Almond fruit
alpha-linolenic acid (ALA)
alpha-lipoic acid
apple cider vinegar
ashwagandha
atractylodes
atractylone
Baikal Skullcap
balsam
banyan
bergamot
beta caryophyllene
beta-hydroxybutyrate
betony
Bifidobacteria
Black Hellebore
black seed
black tea
blackboard tree
Blepharis
brahmi
bupleurum falcatum
butterbur
cannabidiol
Carthamus
Chinese salvia root
Chinese silkvine
chrysanthemum
coenzyme Q10 (CoQ10)
cola nut
Corydalis
creatine
crocin
curcumin
danshen
DHA (docosahexaenoic acid)
docosahexaenoic Acid
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
feverfew
Ficus religiosa
Ficus simplicissima
fish
fish oil
flavanones
flavin mononucleotide
folic acid
frankincense
Gelsemium
ginger
ginkgo biloba
ginkgolides
Ginkgoside
goldthread
gooseberry
gotu kola
Hellebore
Indian frankincense
iridoids
ketone salts
kuding tea
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
lemon balm
Lesser speargrass
linalool
little ironweed
luteolin
magnesium
Meadowsweet
Melatonin
Mesua
Methylxanthine
Moringa
Nardostachys
Niacin (vitamin B3)
Night jessamine
omega-3 fatty acids
Osthole
paeoniflorin
Palmitoylethanolamide (PEA)
Peppermint
Petasines
Phthalides
phytocannabinoids
pine bark
Polygonum
Puerarin
purple butterbur root
Pycnogenol
Rauvolfia
riboflavin (vitamin B2)
Rubiaceae
Rubus
rue
Salmon Oil
Sandalwood
Scabrous Gentian
Sensitive Plant
soursop
specialized pro-resolving mediators (SPMs)
Spikenard
Swertia
Szechuan lovage
turmeric
ubiquinol
Uncaria
Valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
Withanolides
Xanthine
Xanthone
Xanthophyll
Yuzu
Zinc
Zingerone

Products containing 5-methyltetrahydrofolate glucosamine

We currently have no products on Vitabase that contain this ingredient.