Evidence supporting the use of: Alpha-Linolenic Acid
For the health condition: Migraine

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha-Linolenic Acid (ALA) is an essential omega-3 fatty acid found in plant sources such as flaxseed, chia seeds, and walnuts. Its potential role in migraine management has been explored in recent scientific studies. The rationale is based on the anti-inflammatory properties of omega-3 fatty acids, which may modulate the inflammatory pathways and neuronal excitability implicated in migraine pathophysiology. A 2021 randomized controlled trial (BMJ, Ramsden et al.) involving dietary alteration of omega-3 and omega-6 fatty acids showed that increasing dietary omega-3s (including ALA) while reducing omega-6 intake resulted in a modest reduction in headache frequency and severity in chronic migraine sufferers. However, the majority of studies focus on EPA and DHA (long-chain omega-3s from fish oil), with less direct evidence for ALA specifically. Some mechanistic studies suggest that ALA can be converted to EPA and DHA in the body, but the conversion rate is low. There is limited high-quality, direct evidence specifically for ALA, and most clinical recommendations for migraine focus on broader omega-3 intake. Overall, while there is emerging scientific interest and some supportive evidence, it remains preliminary, and ALA cannot yet be considered a first-line treatment for migraine.

More about Alpha-Linolenic Acid
More about Migraine

Other ingredients used for Migraine

5-Hydroxytryptophan (5-HTP)
alpha-linolenic acid (ALA)
ashwagandha
bergamot
beta caryophyllene
black tea
Indian frankincense
bupleurum falcatum
Chinese salvia root
coenzyme Q10 (CoQ10)
turmeric
curcumin
DHA (docosahexaenoic acid)
EPA (eicosapentaenoic acid)
feverfew
fish oil
ginger
ginkgo biloba
gooseberry
gotu kola
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
luteolin
magnesium
Melatonin
Moringa
Niacin (vitamin B3)
omega-3 fatty acids
Peppermint
phytocannabinoids
pine bark
purple butterbur root
riboflavin (vitamin B2)
specialized pro-resolving mediators (SPMs)
Almond fruit
ubiquinol
Valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
Zinc
atractylodes
blackboard tree
Swertia
Szechuan lovage
chrysanthemum
soursop
1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
apple cider vinegar
Albizia
alpha-lipoic acid
atractylone
betony
black seed
Baikal Skullcap
beta-hydroxybutyrate
Blepharis
balsam
banyan
brahmi
butterbur
Bifidobacteria
Black Hellebore
Chinese silkvine
crocin
creatine
cannabidiol
Corydalis
Carthamus
cola nut
docosahexaenoic Acid
danshen
eicosapentaenoic acid
folic acid
flavin mononucleotide
Ficus religiosa
fish
flavanones
Ficus simplicissima
frankincense
goldthread
Gelsemium
ginkgolides
Ginkgoside
Hellebore
iridoids
ketone salts
kuding tea
lemon balm
Lesser speargrass
little ironweed
linalool
Mesua
Methylxanthine
Meadowsweet
Nardostachys
Night jessamine
Osthole
Puerarin
Petasines
Phthalides
paeoniflorin
Pycnogenol
Polygonum
Palmitoylethanolamide (PEA)
rue
Rubus
Rauvolfia
Rubiaceae
Spikenard
Sensitive Plant
Salmon Oil
Sandalwood
Scabrous Gentian
Uncaria
Withanolides
Xanthine
Xanthophyll
Xanthone
Yuzu
Zingerone

Products containing Alpha-Linolenic Acid

We currently have no products on Vitabase that contain this ingredient.